Virus-Mimetic Nanoparticles for the Therapy of Mesangial Cells in Diabetic Nephropathy

URN to cite this document:: urn:nbn:de:bvb:355-epub-461702
DOI to cite this document:: 10.5283/epub.46170

Fleischmann, Daniel

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Date of publication of this fulltext: 30 Jun 2021 07:56

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Item type:	Thesis of the University of Regensburg (PhD)
Open Access Type:	Primary Publication
Date:	30 June 2021
Referee:	Prof. Dr. Achim Göpferich
Date of exam:	18 June 2021
Institutions:	Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Keywords:	Virus-mimetic Nanoparticles, Anti-Fibrotic Therapy, Renal Mesangial Cells
Dewey Decimal Classification:	500 Science > 500 Natural sciences & mathematics 500 Science > 540 Chemistry & allied sciences
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	46170

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Abstract (English)

In this work, adenovirus-mimetic nanoparticles with a sequential target cell recognition were manufactured to treat renal mesangial cells in diabetic nephropathy via cell-specific delivery of anti-fibrotic agent cinaciguat.

Translation of the abstract (German)

In dieser Arbeit wurden Adenovirus-mimetische Nanopartikel mit einem sequenziellen Erkennungsprinzip für renale Mesangialzellen hergestellt. Ziel war es dabei, den antifibrotischen Wirkstoff Cinaciguat zielgerichtet zu Mesangialzellen zu transportieren, um diese im Rahmen der Diabetischen Nephropathie zu therapieren.

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