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Virus-Mimetic Nanoparticles for the Therapy of Mesangial Cells in Diabetic Nephropathy

URN to cite this document:
urn:nbn:de:bvb:355-epub-461702
DOI to cite this document:
10.5283/epub.46170
Fleischmann, Daniel
Date of publication of this fulltext: 30 Jun 2021 07:56


Abstract (English)

In this work, adenovirus-mimetic nanoparticles with a sequential target cell recognition were manufactured to treat renal mesangial cells in diabetic nephropathy via cell-specific delivery of anti-fibrotic agent cinaciguat.

Translation of the abstract (German)

In dieser Arbeit wurden Adenovirus-mimetische Nanopartikel mit einem sequenziellen Erkennungsprinzip für renale Mesangialzellen hergestellt. Ziel war es dabei, den antifibrotischen Wirkstoff Cinaciguat zielgerichtet zu Mesangialzellen zu transportieren, um diese im Rahmen der Diabetischen Nephropathie zu therapieren.


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