Steroid-refractory chronic graft-versus-host disease: treatment options and patient management

URN to cite this document:: urn:nbn:de:bvb:355-epub-462967
DOI to cite this document:: 10.5283/epub.46296

Wolff, Daniel

; Fatobene, Giancarlo ; Rocha, Vanderson ; Kröger, Nicolaus ; Flowers, Mary E.

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Date of publication of this fulltext: 07 Jul 2021 06:52

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Abstract

Chronic graft-versus-host disease (cGVHD) is one of the major causes of late mortality after allogenic hematopoietic stem cell transplantation. Moderate-to-severe cGVHD is associated with poor health-related quality of life and substantial disease burden. While corticosteroids with or without calcineurin inhibitors comprise the first-line treatment option, the prognosis for patients with ...