Effect of Particle Size and Surface Chemistry of Photon Upconversion Nanoparticles on Analog and Digital Immunoassays for Cardiac Troponin

URN to cite this document:: urn:nbn:de:bvb:355-epub-464386
DOI to cite this document:: 10.5283/epub.46438

Brandmeier, Julian C.

; Raiko, Kirsti ; Farka, Zdeněk

; Peltomaa, Riikka ; Mickert, Matthias J.

; Hlaváček, Antonín ; Skládal, Petr ; Soukka, Tero ; Gorris, Hans H.

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Date of publication of this fulltext: 28 Jul 2021 09:35

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Abstract

Sensitive immunoassays are required for troponin, a low-abundance cardiac biomarker in blood. In contrast to conventional (analog) assays that measure the integrated signal of thousands of molecules, digital assays are based on counting individual biomarker molecules. Photon-upconversion nanoparticles (UCNP) are an excellent nanomaterial for labeling and detecting single biomarker molecules ...