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Effect of Particle Size and Surface Chemistry of Photon Upconversion Nanoparticles on Analog and Digital Immunoassays for Cardiac Troponin

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Brandmeier, Julian C. ; Raiko, Kirsti ; Farka, Zdeněk ; Peltomaa, Riikka ; Mickert, Matthias J. ; Hlaváček, Antonín ; Skládal, Petr ; Soukka, Tero ; Gorris, Hans H.
License: Creative Commons Attribution Non-commercial 4.0
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Date of publication of this fulltext: 28 Jul 2021 09:35

This publication is part of the DEAL contract with Wiley.


Sensitive immunoassays are required for troponin, a low-abundance cardiac biomarker in blood. In contrast to conventional (analog) assays that measure the integrated signal of thousands of molecules, digital assays are based on counting individual biomarker molecules. Photon-upconversion nanoparticles (UCNP) are an excellent nanomaterial for labeling and detecting single biomarker molecules ...


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