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Temporal autoregulation during human PU.1 locus SubTAD formation

Rosenbauer, Frank ; Dugas, Martin ; Gröschel, Stefan ; Lenz, Georg ; Delwel, Ruud ; Rehli, Michael ; Minderjahn, Julia ; Perrod, Chiara ; Wethmar, Klaus ; Gebhard, Claudia ; Weilemann, Andre ; Bindels, Eric ; Tönges, Alexander ; Erdmann, Tabea ; König, Thorsten ; Kruse, Sabrina ; van Riel, Boet ; Walter, Carolin ; Schuetzmann, Daniel



Abstract

Epigenetic control of gene expression occurs within discrete spatial chromosomal units called topologically associating domains (TADs), but the exact spatial requirements of most genes are unknown; this is of particular interest for genes involved in cancer. We therefore applied high-resolution chromosomal conformation capture sequencing to map the three-dimensional (3D) organization of the human ...

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