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The sacrificial inactivation of the blue-light photosensor cryptochrome from Drosophila melanogaster

Kutta, Roger Jan ; Archipowa, Nataliya ; Scrutton, Nigel Shaun


Drosophila melanogaster cryptochrome functions as the primary blue-light receptor that mediates circadian photo entrainment. Absorption of a photon leads to reduction of the protein-bound FAD via consecutive electron transfer along a conserved tryptophan tetrad resembling the signalling state required for conformational changes and induction of subsequent signalling cascades. However, how the ...


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