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Differential multivariable risk prediction of appropriate shock versus competing mortality - A prospective cohort study to estimate benefits from ICD therapy

Bergau, Leonard ; Willems, Rik ; Sprenkeler, David J. ; Fischer, Thomas H. ; Flevari, Panayota ; Hasenfuß, Gerd ; Katsaras, Dimitrios ; Kirova, Aleksandra ; Lehnart, Stephan E. ; Lüthje, Lars ; Röver, Christian ; Seegers, Joachim ; Sossalla, Samuel ; Dunnink, Albert ; Sritharan, Rajevaa ; Tuinenburg, Anton E. ; Vandenberk, Bert ; Vos, Marc A. ; Wijers, Sofieke C. ; Friede, Tim ; Zabel, Markus


Background and objective: We prospectively investigated combinations of risk stratifiers including multiple EP diagnostics in a cohort study of ICD patients. Methods: For 672 enrolled patients, we collected history, LVEF, EP study and T-wave altemans testing, 24-h Hotter, IsiT-proBNP, and the eGFR All-cause mortality and first appropriate ICD shock were predefined endpoints. Results: The 635 ...


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