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Control of hepatic gluconeogenesis by Argonaute2

Yan, Xin ; Wang, Zhen ; Bishop, Christopher A. ; Weitkunat, Karolin ; Feng, Xiao ; Tarbier, Marcel ; Luo, Jiankai ; Friedländer, Marc R. ; Burkhardt, Ralph ; Klaus, Susanne ; Willnow, Thomas E. ; Poy, Matthew N.



Abstract

Objective: The liver performs a central role in regulating energy homeostasis by increasing glucose output during fasting. Recent studies on Argonaute2 (Ago2), a key RNA-binding protein mediating the microRNA pathway, have illustrated its role in adaptive mechanisms according to changes in metabolic demand. Here we sought to characterize the functional role of Ago2 in the liver in the maintenance ...

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