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Perioperative Systemic Chemotherapy, Cytoreductive Surgery, and Hyperthermic Intraperitoneal Chemotherapy in Patients With Colorectal Peritoneal Metastasis: Results of the Prospective Multicenter Phase 2 COMBATAC Trial

Glockzin, Gabriel ; Zeman, Florian ; Croner, Roland S. ; Königsrainer, Alfred ; Pelz, Jörg ; Ströhlein, Michael A. ; Rau, Beate ; Arnold, Dirk ; Koller, Michael ; Schlitt, Hans J. ; Piso, Pompiliu


The prospective phase 2 COMBATAC (COMBined Anticancer Treatment of Advanced Colorectal cancer) trial evaluated perioperative systemic chemotherapy + cetuximab combined with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in 26 patients with peritoneal metastatic colorectal cancer. The combined treatment regimen is safe and feasible, and is associated with ...


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