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Arginine-rich cell-penetrating peptides induce membrane multilamellarity and subsequently enter via formation of a fusion pore

Allolio, Christoph ; Magarkar, Aniket ; Jurkiewicz, Piotr ; Baxová, Katarína ; Javanainen, Matti ; Mason, Philip E. ; Šachl, Radek ; Cebecauer, Marek ; Hof, Martin ; Horinek, Dominik ; Heinz, Veronika ; Rachel, Reinhard ; Ziegler, Christine M. ; Schröfel, Adam ; Jungwirth, Pavel


Arginine-rich cell-penetrating peptides do not enter cells by directly passing through a lipid membrane; they instead passively enter vesicles and live cells by inducing membrane multilamellarity and fusion. The molecular picture of this penetration mode, which differs qualitatively from the previously proposed direct mechanism, is provided by molecular dynamics simulations. The kinetics of ...


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