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Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis

Cambré, Isabelle ; Gaublomme, Djoere ; Burssens, Arne ; Jacques, Peggy ; Schryvers, Nadia ; De Muynck, Amélie ; Meuris, Leander ; Lambrecht, Stijn ; Carter, Shea ; de Bleser, Pieter ; Saeys, Yvan ; Van Hoorebeke, Luc ; Kollias, George ; Mack, Matthias ; Simoens, Paul ; Lories, Rik ; Callewaert, Nico ; Schett, Georg ; Elewaut, Dirk


Many pro-inflammatory pathways leading to arthritis have global effects on the immune system rather than only acting locally in joints. The reason behind the regional and patchy distribution of arthritis represents a longstanding paradox. Here we show that biomechanical loading acts as a decisive factor in the transition from systemic autoimmunity to joint inflammation. Distribution of ...


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