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Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart

Dybkova, Nataliya ; Ahmad, Shakil ; Pabel, Steffen ; Tirilomis, Petros ; Hartmann, Nico ; Fischer, Thomas H. ; Bengel, Philipp ; Tirilomis, Theodoros ; Ljubojevic, Senka ; Renner, André ; Gummert, Jan ; Ellenberger, David ; Wagner, Stefan ; Frey, Norbert ; Maier, Lars S. ; Streckfuss-Bömeke, Katrin ; Hasenfuss, Gerd ; Sossalla, Samuel


Aims In heart failure (HF), enhanced persistent Na+ current (I-NaL) exerts detrimental effects on cellular electrophysiology and can induce arrhythmias. However, the underlying regulatory mechanisms remain unclear. Our aim was to potentially investigate the regulation and electrophysiological contribution of neuronal sodium channel Na(V)1.8 in failing human heart and eventually to reveal a novel ...


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