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OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism

Kentala, Henriikka ; Koponen, Annika ; Vihinen, Helena ; Pirhonen, Juho ; Liebisch, Gerhard ; Pataj, Zoltan ; Kivelä, Annukka ; Li, Shiqian ; Karhinen, Leena ; Jääskeläinen, Eeva ; Andrews, Robert ; Meriläinen, Leena ; Matysik, Silke ; Ikonen, Elina ; Zhou, You ; Jokitalo, Eija ; Olkkonen, Vesa M.



Abstract

ORP2 is a ubiquitously expressed OSBP-related protein previously implicated in endoplasmic reticulum (ER)lipid droplet (LD) contacts, triacylglycerol (TG) metabolism, cholesterol transport, adrenocortical steroidogenesis, and actin-dependent cell dynamics. Here, we characterize the role of ORP2 in carbohydrate and lipid metabolism by employing ORP2-knockout (KO) hepatoma cells (HuH7) generated by ...

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