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Depletion of Collagen IX Alpha1 Impairs Myeloid Cell Function

Probst, Kristina ; Stermann, Jacek ; von Bomhard, Inga ; Etich, Julia ; Pitzler, Lena ; Niehoff, Anja ; Bluhm, Björn ; Xu, Haifeng C. ; Lang, Philipp A. ; Chmielewski, Markus ; Abken, Hinrich ; Blissenbach, Birgit ; Machova, Alzbeta ; Papadopoulou, Nikoletta ; Brachvogel, Bent



Abstract

The trabecular extracellular matrix (ECM) forms a three-dimensional scaffold to stabilize the bone marrow, provide substrates for cell-matrix interactions and retain, present or release signals to modulate hematopoietic stem and progenitor cell development. However, the impact of trabecular ECM components on hematopoiesis has been poorly studied. Using collagen IX alpha1 - deficient ...

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