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Intra‑tumoral treatment with oxygen‑ozone in glioblastoma: A systematic literature search and results of a case series

Megele, Richard ; Riemenschneider, Markus ; Dodoo‑Schittko, Frank ; Feyrer, Matthias ; Kleindienst, Andrea


Despite progress in surgery and radiochemotherapy, the prognosis of glioblastoma (GB) remains poor. GB cells exhibit a preference for hypoxia to maintain their tumor-forming capacity. Treatment strategies utilizing oxygen (O-2) or ozone (O-3) and generating reactive oxygen species induce cell growth inhibition and apoptosis. The anti-tumorigenic properties of O-2-O-3 are accompanied by a key role ...


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