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The renal vasodilatory effect of prostaglandins is ameliorated in isolated-perfused kidneys of endotoxemic mice

Meurer, Manuel ; Ebert, Katharina ; Schweda, Frank ; Höcherl, Klaus



Abstract

Endotoxemia-related acute kidney injury (AKI) is associated with increased formation of prostaglandins, which may serve as a compensatory mechanism to maintain renal function. We hypothesized that an increase of renal EP2 or EP4 receptors and/or a downregulation of renal EP1 and EP3 receptors enhances PGE(2)-induced renal vasodilatation. Injection of lipopolysaccharide (LPS; 3mg/kg i.p.) ...

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