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Anoctamin-6 regulates ADAM sheddase function

Veit, Martin ; Koyro, Katharina Isabelle ; Ahrens, Björn ; Bleibaum, Florian ; Munz, Martin ; Rövekamp, Hagen ; Andrä, Jörg ; Schreiber, Rainer ; Kunzelmann, Karl ; Sommer, Anselm ; Bhakdi, Sucharit ; Reiss, Karina


ADAM17, a prominent member of the "Disintegrin and Metalloproteinase" (ADAM) family, controls vital cellular functions through cleavage of transmembrane substrates including TGF-alpha, Amphiregulin (AREG) and TNF-Receptor 1 (TNFR1). We recently presented evidence that surface exposure of phosphatidylserine (PS) is pivotal for ADAM17 to exert sheddase activity. Anoctamin-6 (ANO6) has ...


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