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Dynamics of Genome Alterations in Crohn's Disease–Associated Colorectal Carcinogenesis

Hirsch, Daniela ; Wangsa, Darawalee ; Zhu, Yuelin J. ; Hu, Yue ; Edelman, Daniel C. ; Meltzer, Paul S. ; Heselmeyer-Haddad, Kerstin ; Ott, Claudia ; Kienle, Peter ; Galata, Christian ; Horisberger, Karoline ; Ried, Thomas ; Gaiser, Timo



Abstract

Purpose: Patients with inflammatory bowel diseases, that is, ulcerative colitis and Crohn's disease (CD), face an increased risk of developing colorectal cancer (CRC). Evidence, mainly from ulcerative colitis, suggests that TP53 mutations represent an initial step in the progression from inflamed colonic epithelium to CRC. However, the pathways involved in the evolution of CRC in patients with CD ...

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