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The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice

Kindt, Alida ; Liebisch, Gerhard ; Clavel, Thomas ; Haller, Dirk ; Hörmannsperger, Gabriele ; Yoon, Hongsup ; Kolmeder, Daniela ; Sigruener, Alexander ; Krautbauer, Sabrina ; Seeliger, Claudine ; Ganzha, Alexandra ; Schweizer, Sabine ; Morisset, Rosalie ; Strowig, Till ; Daniel, Hannelore ; Helm, Dominic ; Küster, Bernhard ; Krumsiek, Jan ; Ecker, Josef



Abstract

Interactions between the gut microbial ecosystem and host lipid homeostasis are highly relevant to host physiology and metabolic diseases. We present a comprehensive multiomics view of the effect of intestinal microbial colonization on hepatic lipid metabolism, integrating transcriptomic, proteomic, phosphoproteomic, and lipidomic analyses of liver and plasma samples from germfree and specific ...

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