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xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression

Ji, Xiangming ; Qian, Jun ; Rahman, S. M. Jamshedur ; Siska, Peter J. ; Zou, Yong ; Harris, Bradford K. ; Hoeksema, Megan D. ; Trenary, Irina A. ; Heidi, Chen ; Eisenberg, Rosana ; Rathmell, Jeffrey C. ; Young, Jamey D. ; Massion, Pierre P.



Abstract

Many tumors increase uptake and dependence on glucose, cystine or glutamine. These basic observations on cancer cell metabolism have opened multiple new diagnostic and therapeutic avenues in cancer research. Recent studies demonstrated that smoking could induce the expression of xCT (SLC7A11) in oral cancer cells, suggesting that overexpression of xCT may support lung tumor progression. We ...

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