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Comparative proteomics reveals a diagnostic signature for pulmonary head‐and‐neck cancer metastasis

Bohnenberger, Hanibal ; Kaderali, Lars ; Ströbel, Philipp ; Yepes, Diego ; Plessmann, Uwe ; Dharia, Neekesh V ; Yao, Sha ; Heydt, Carina ; Merkelbach‐Bruse, Sabine ; Emmert, Alexander ; Hoffmann, Jonatan ; Bodemeyer, Julius ; Reuter‐Jessen, Kirsten ; Lois, Anna‐Maria ; Dröge, Leif Hendrik ; Baumeister, Philipp ; Walz, Christoph ; Biggemann, Lorenz ; Walter, Roland ; Häupl, Björn ; Comoglio, Federico ; Pan, Kuan‐Ting ; Scheich, Sebastian ; Lenz, Christof ; Küffer, Stefan ; Bremmer, Felix ; Kitz, Julia ; Sitte, Maren ; Beißbarth, Tim ; Hinterthaner, Marc ; Sebastian, Martin ; Lotz, Joachim ; Schildhaus, Hans‐Ulrich ; Wolff, Hendrik ; Danner, Bernhard C ; Brandts, Christian ; Büttner, Reinhard ; Canis, Martin ; Stegmaier, Kimberly ; Serve, Hubert ; Urlaub, Henning ; Oellerich, Thomas



Abstract

Patients with head-and-neck cancer can develop both lung metastasis and primary lung cancer during the course of their disease. Despite the clinical importance of discrimination, reliable diagnostic biomarkers are still lacking. Here, we have characterised a cohort of squamous cell lung (SQCLC) and head-and-neck (HNSCC) carcinomas by quantitative proteomics. In a training cohort, we quantified ...

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