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Pharmacokinetics of cefuroxime in infants and neonates undergoing cardiac surgery

Gertler, Ralph ; Gruber, Michael ; Wiesner, Gunther ; Grassin-Delyle, Stanislas ; Urien, Saïk ; Tassani-Prell, Peter ; Martin, Klaus


AIMS Very little data exist regarding the effect of cardiopulmonary bypass (CPB) on cefuroxime (CXM) pharmacokinetics in children less than one year of age. METHODS 50 mg kg(-1) CXM i.v. after induction were followed by 75mg kg(-1) into the CPB circuit. In 42 patients undergoing cardiac surgery, 15-20 samples were obtained between 5 and 360 min after the first dose. Total CXM concentrations were ...


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