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Safety and efficacy of rasagiline as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomised, double-blind, parallel-group, placebo-controlled, phase 2 trial

Ludolph, Albert C. ; Schuster, Joachim ; Dorst, Johannes ; Dupuis, Luc ; Dreyhaupt, Jens ; Weishaupt, Jochen H. ; Kassubek, Jan ; Weiland, Ulrike ; Petri, Susanne ; Meyer, Thomas ; Grosskreutz, Julian ; Schrank, Berthold ; Boentert, Matthias ; Emmer, Alexander ; Hermann, Andreas ; Zeller, Daniel ; Prudlo, Johannes ; Winkler, Andrea S. ; Grehl, Torsten ; Heneka, Michael T. ; Wollebæk Johannesen, Siw ; Göricke, Bettina ; Funke, Andreas ; Kettemann, Dagmar ; Meyer, Robert ; Meyer, Thomas ; Grehl, Torsten ; Gruhn, Kai ; Schwenkreis, Peter ; Stude, Philipp ; Heneka, Michael T. ; Kurzwelly, Delia ; Hermann, Andreas ; Storch, Alexander ; Richter, Nicole ; Frank, Tobias ; Göricke, Bettina ; Hein, Katharina ; Emmer, Alexander ; Hanisch, Frank ; Hanke, Dagmar ; Kraya, Torsten ; Posa, Andreas ; Romanakova, Martina ; Schilling, Susanne ; Abdulla, Susanne ; Böselt, Sebastian ; Hanke, Dagmar ; Janssen, Claas ; Lange, Imken ; Kobeleva, Xenia ; Körner, Sonja ; Kollewe, Katja ; Osmanovic, Alma ; Petri, Susanne ; Scharn, Nicole ; Rath, Klaus J. ; Dahms, Christiane ; Grosskreutz, Julian ; Gunkel, Anne ; Heiling, Bianka ; Ringer, Thomas ; Smesny, Uta ; Baumeister, Sarah ; Berthele, Achim ; Bublitz, Sarah ; Winkler, Andrea S. ; Akova-Öztürk, Esra ; Boentert, Matthias ; Stubbe-Dräger, Bianca ; Rahmann, Alexandra ; Young, Charlotte ; Young, Peter ; Baldaranov, Dobri ; Bogdahn, Ulrich ; Wollebæk Johannesen, Siw ; Khomenko, Andrei ; Schulte-Mattler, Wilhelm ; Stadler, Christina ; Husung, Susanne ; Prudlo, Johannes ; Tesar, Simone ; Dargah-Zaden, Nigar ; Last, Christina ; Langer, Eva ; Ludolph, Albert C. ; Weishaupt, Jochen H. ; Weiland, Ulrike ; Lauenstein, Ann-Sophie ; Lensch, Eckard ; Mc Farlane, Carolyn ; Fischer-Brasse, Heike ; Orbán, Klara ; Schrank, Bertold ; Schürger, Sonja ; Klebe, Stephan ; Kraft, Peter ; Musacchio, Thomas ; Seiler, Carola ; Zeller, Daniel



Abstract

Background Rasagiline, a monoamine oxidase B inhibitor with neuroprotective potential in Parkinson's disease, has shown a disease-modifying effect in the SOD1-Gly93Ala low-expressing mouse model of amyotrophic lateral sclerosis, both alone and in combination with riluzole. We sought to test whether or not rasagiline 1 mg/day can prolong survival in patients with amyotrophic lateral sclerosis also ...

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