; Thorsen, Jonathan
; Tian, Chao ; Schoettler, Nathan ; Flores, Carlos ; Abdellaoui, Abdel ; Ahluwalia, Tarunveer S.
; Alves, Alexessander C. ; Amaral, Andre F. S.
; Antó, Josep M.
; Arnold, Andreas ; Barreto-Luis, Amalia ; Baurecht, Hansjörg
; van Beijsterveldt, Catharina E. M. ; Bleecker, Eugene R. ; Bonàs-Guarch, Sílvia
; Boomsma, Dorret I. ; Brix, Susanne ; Bunyavanich, Supinda ; Burchard, Esteban G. ; Chen, Zhanghua ; Curjuric, Ivan ; Custovic, Adnan
; Den Dekker, Herman T. ; Dharmage, Shyamali C.
; Dmitrieva, Julia ; Duijts, Liesbeth ; Ege, Markus J.
; Gauderman, W. James ; Georges, Michel ; Gieger, Christian ; Gilliland, Frank ; Granell, Raquel ; Gui, Hongsheng
; Hansen, Torben
; Heinrich, Joachim
; Henderson, John ; Hernandez-Pacheco, Natalia ; Holt, Patrick
; Imboden, Medea ; Jaddoe, Vincent W. V. ; Jarvelin, Marjo-Riitta ; Jarvis, Deborah L. ; Jensen, Kamilla K. ; Jónsdóttir, Ingileif ; Kabesch, Michael
; Kaprio, Jaakko
; Kumar, Ashish ; Lee, Young-Ae ; Levin, Albert M. ; Li, Xingnan ; Lorenzo-Diaz, Fabian ; Melén, Erik ; Mercader, Josep M. ; Meyers, Deborah A. ; Myers, Rachel ; Nicolae, Dan L. ; Nohr, Ellen A. ; Palviainen, Teemu
; Paternoster, Lavinia ; Pennell, Craig E. ; Pershagen, Göran ; Pino-Yanes, Maria
; Probst-Hensch, Nicole M. ; Rüschendorf, Franz ; Simpson, Angela ; Stefansson, Kari ; Sunyer, Jordi
; Sveinbjornsson, Gardar ; Thiering, Elisabeth ; Thompson, Philip J. ; Torrent, Maties ; Torrents, David ; Tung, Joyce Y. ; Wang, Carol A.
; Weidinger, Stephan ; Weiss, Scott ; Willemsen, Gonneke ; Williams, L. Keoki ; Ober, Carole
; Hinds, David A. ; Ferreira, Manuel A. ; Bisgaard, Hans
; Strachan, David P. ; Bønnelykke, Klaus | Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Nature Genetics | ||||
| Publisher: | Nature | ||||
| Place of Publication: | NEW YORK | ||||
| Volume: | 50 | ||||
| Number of Issue or Book Chapter: | 8 | ||||
| Page Range: | pp. 1072-1080 | ||||
| Date: | 2018 | ||||
| Institutions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin | ||||
| Identification Number: |
| ||||
| Keywords: | HAY-FEVER; CELL DEVELOPMENT; DENDRITIC CELLS; EXPRESSION; VARIANTS; ASTHMA; RECEPTOR; HERITABILITY; METAANALYSIS; DISEASES | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Partially | ||||
| Item ID: | 46921 |
Abstract
Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries(1,2). To elucidate the genetic architecture and understand the underlying disease mechanisms, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk ...

Abstract
Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries(1,2). To elucidate the genetic architecture and understand the underlying disease mechanisms, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic rhinitis, including 20 loci not previously associated with allergic rhinitis, which were confirmed in a replication phase of 60,720 cases and 618,527 controls. Functional annotation implicated genes involved in various immune pathways, and fine mapping of the HLA region suggested amino acid variants important for antigen binding. We further performed genome-wide association study (GWAS) analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis, which suggested shared genetic mechanisms across rhinitis-related traits. Future studies of the identified loci and genes might identify novel targets for treatment and prevention of allergic rhinitis.
Metadata last modified: 28 Jun 2024 05:19
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