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Fibroblastic reticular cells initiate immune responses in visceral adipose tissues and secure peritoneal immunity

Perez-Shibayama, Christian ; Gil-Cruz, Cristina ; Cheng, Hung-Wei ; Onder, Lucas ; Printz, Andrea ; Mörbe, Urs ; Novkovic, Mario ; Li, Conglei ; Lopez-Macias, Constantino ; Buechler, Matthew B. ; Turley, Shannon J. ; Mack, Matthias ; Soneson, Charlotte ; Robinson, Mark D. ; Scandella, Elke ; Gommerman, Jennifer ; Ludewig, Burkhard



Zusammenfassung

Immune protection of the body cavities depends on the swift activation of innate and adaptive immune responses in nonclassical secondary lymphoid organs known as fat-associated lymphoid clusters (FALCs). Compared with classical secondary lymphoid organs such as lymph nodes and Peyer's patches, FALCs develop along distinct differentiation trajectories and display a reduced structural complexity. ...

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