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Metric substage according to micro and extensive lamina propria invasion improves prognostics in T1 bladder cancer

Fransen van de Putte, Elisabeth E. ; Otto, Wolfgang ; Hartmann, Arndt ; Bertz, Simone ; Mayr, Roman ; Bründl, Johannes ; Breyer, Johannes ; Manach, Quentin ; Compérat, Eva M. ; Boormans, Joost L. ; Bosschieter, Judith ; Jewett, Michael A. S. ; Stoehr, Robert ; van Leenders, Geert J. L. H. ; Nieuwenhuijzen, Jakko A. ; Zlotta, Alexandre R. ; Hendricksen, Kees ; Rouprêt, Morgan ; Burger, Maximilian ; van der Kwast, Theo H. ; van Rhijn, Bas W. G.


Background: Reliable prognosticators for T1 bladder cancer (T1BC) are urgently needed. OBJECTIVE: To compare the prognostic value of 2 substage systems for T1BC in patients treated by transurethral resection (TUR) and adjuvant bacillus Calmette-Guerin therapy. Design, setting, and participants: The slides of 601 primary T1BCs from four institutes were reviewed by 2 uropathologists and substaged ...


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