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Cardiac unloading by LVAD support differentially influences components of the cGMP–PKG signaling pathway in ischemic and dilated cardiomyopathy

Persoon, Sven ; Paulus, Michael ; Hirt, Stephan ; Jungbauer, Carsten ; Dietl, Alexander ; Luchner, Andreas ; Schmid, Christof ; Maier, Lars S. ; Birner, Christoph



Zusammenfassung

Implantation of left ventricular assist devices (LVADs) as bridge to transplant in end-stage heart failure allows for analyzing reverse remodeling processes of the supported heart. Whether this therapy influences the cGMP-PKG signaling pathway, which is currently under thorough investigation for developing new heart failure therapeutics, is unknown. In fourteen end-stage heart failure patients (8 ...

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