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Endothelial C-Type Natriuretic Peptide Acts on Pericytes to Regulate Microcirculatory Flow and Blood Pressure

Špiranec, Katarina ; Chen, Wen ; Werner, Franziska ; Nikolaev, Viacheslav O. ; Naruke, Takashi ; Koch, Franziska ; Werner, Andrea ; Eder-Negrin, Petra ; Diéguez-Hurtado, Rodrigo ; Adams, Ralf H. ; Baba, Hideo A. ; Schmidt, Hannes ; Schuh, Kai ; Skryabin, Boris V. ; Movahedi, Kiavash ; Schweda, Frank ; Kuhn, Michaela



Abstract

Background: Peripheral vascular resistance has a major impact on arterial blood pressure levels. Endothelial C-type natriuretic peptide (CNP) participates in the local regulation of vascular tone, but the target cells remain controversial. The cGMP-producing guanylyl cyclase-B (GC-B) receptor for CNP is expressed in vascular smooth muscle cells (SMCs). However, whereas endothelial cell-specific ...

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