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Hypertonicity-enforced BCL-2 addiction unleashes the cytotoxic potential of death receptors

Sirtl, Simon ; Knoll, Gertrud ; Trinh, Dieu Thuy ; Lang, Isabell ; Siegmund, Daniela ; Gross, Stefanie ; Schuler-Thurner, Beatrice ; Neubert, Patrick ; Jantsch, Jonathan ; Wajant, Harald ; Ehrenschwender, Martin



Zusammenfassung

Attempts to exploit the cytotoxic activity of death receptors (DR) for treating cancer have thus far been disappointing. DR activation in most malignant cells fails to trigger cell death and may even promote tumor growth by activating cell death-independent DR-associated signaling pathways. Overcoming apoptosis resistance is consequently a prerequisite for successful clinical exploitation of DR ...

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