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PIK3CA mutations are specifically localized to lymphatic endothelial cells of lymphatic malformations

Phillips, Wayne A ; Blesinger, Hannah ; Kaulfuß, Silke ; Aung, Thiha ; Schwoch, Sonja ; Prantl, Lukas ; Rößler, Jochen ; Wilting, Jörg ; Becker, Jürgen



Zusammenfassung

Lymphatic malformations (LM) are characterized by the overgrowth of lymphatic vessels during pre- and postnatal development. Macrocystic, microcystic and combined forms of LM are known. The cysts are lined by lymphatic endothelial cells (LECs). Resection and sclerotherapy are the most common treatment methods. Recent studies performed on LM specimens in the United States of America have ...

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