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Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson’s Disease

Sommer, Annika ; Marxreiter, Franz ; Krach, Florian ; Fadler, Tanja ; Grosch, Janina ; Maroni, Michele ; Graef, Daniela ; Eberhardt, Esther ; Riemenschneider, Markus J. ; Yeo, Gene W. ; Kohl, Zacharias ; Xiang, Wei ; Gage, Fred H. ; Winkler, Jürgen ; Prots, Iryna ; Winner, Beate



Abstract

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive degeneration of midbrain neurons (MBNs). Recent evidence suggests contribution of the adaptive immune system in PD. Here, we show a role for human T lymphocytes as cell death inducers of induced pluripotent stem cell (iPSC)-derived MBNs in sporadic PD. Higher Th17 frequencies were found in the blood of PD ...

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