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A novel model to study neonatal Escherichia colisepsis and the effect of treatment on the human immune system using humanized mice

Schlieckau, Florian ; Schulz, Daniela ; Fill Malfertheiner, Sara ; Entleutner, Kathrin ; Seelbach-Goebel, Birgit ; Ernst, Wolfgang



Abstract

Problem Neonatal sepsis is a serious threat especially for preterm infants. As existing in vitro and in vivo models have limitations, we generated a novel neonatal sepsis model using humanized mice and tested the effect of Betamethasone and Indomethacin which are used in the clinic in case of premature birth. Method of study Humanized mice were infected with Escherichia coli (E. coli). ...

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