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Humanization of bone and bone marrow in an orthotopic site reveals new potential therapeutic targets in osteosarcoma

Wagner, Ferdinand ; Holzapfel, Boris M. ; McGovern, Jacqui A. ; Shafiee, Abbas ; Baldwin, Jeremy G. ; Martine, Laure C. ; Lahr, Christoph A. ; Wunner, Felix M. ; Friis, Thor ; Bas, Onur ; Boxberg, Melanie ; Prodinger, Peter M. ; Shokoohmand, Ali ; Moi, Davide ; Mazzieri, Roberta ; Loessner, Daniela ; Hutmacher, Dietmar W.


Background: Existing preclinical murine models often fail to predict effects of anti-cancer drugs. In order to minimize interspecies-differences between murine hosts and human bone tumors of in vivo xenograft platforms, we tissue-engineered a novel orthotopic humanized bone model. Methods: Orthotopic humanized tissue engineered bone constructs (ohTEBC) were fabricated by 3D printing of ...


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