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Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-Cell Targets in Human IDH-Mutant Glioma

Dettling, Steffen ; Stamova, Slava ; Warta, Rolf ; Schnölzer, Martina ; Rapp, Carmen ; Rathinasamy, Anchana ; Reuss, David ; Pocha, Kolja ; Roesch, Saskia ; Jungk, Christine ; Warnken, Uwe ; Eckstein, Volker ; Grabe, Niels ; Schramm, Christoph ; Weigand, Markus A. ; von Deimling, Andreas ; Unterberg, Andreas ; Beckhove, Philipp ; Herold-Mende, Christel



Abstract

Purpose:Successful immunotherapies for IDH(mut )gliomas require better knowledge of T-cell target antigens. Here, we elucidated their antigen repertoire recognized by spontaneous T-cell responses using an unbiased proteomic approach. Experimental Design:Protein fractionations of tissue lysates from IDH(mut )gliomas (n = 4) were performed. Fractions were tested by IFN gamma ELISpot assay for ...

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