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Relationship of Catalysis and Active Site Loop Dynamics in the (βα)8-Barrel Enzyme Indole-3-glycerol Phosphate Synthase

Schlee, Sandra ; Klein, Thomas ; Schumacher, Magdalena ; Nazet, Julian ; Merkl, Rainer ; Steinhoff, Heinz-Jürgen ; Sterner, Reinhard



Abstract

It is important to understand how the catalytic activity of enzymes is related to their conformational flexibility. We have studied this activity-flexibility correlation using the example of indole-3-glycerol phosphate synthase from Sulfolobus solfataricus (ssIGPS), which catalyzes the fifth step in the biosynthesis of tryptophan. ssIGPS is a thermostable representative of enzymes with the ...

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