Startseite UR
Drexler, Lukas, Fürtges, Torben F., Rudack, Till
und Sterner, Reinhard
(2025)
On the Origin of Substrate Specificity of Enzymes from the Amidohydrolase Superfamily.
Angewandte Chemie International Edition.
Kinateder, Thomas
, Drexler, Lukas, Duran, Cristina, Osuna, Sílvia und Sterner, Reinhard
(2025)
A naturally occurring standalone TrpB enzyme provides insights into allosteric communication within tryptophan synthase.
Protein Science 34 (4), e70103.
Hiefinger, Caroline, Zinner, Gabriel, Fürtges, Torben F., Narindoshvili, Tamari, Schindler, Sebastian
, Bruckmann, Astrid
, Rudack, Till
, Raushel, Frank M.
und Sterner, Reinhard
(2025)
Photocontrolling the Enantioselectivity of a Phosphotriesterase via Incorporation of a Light-Responsive Unnatural Amino Acid.
JACS Au 5 (2), S. 858-870.
Hiefinger, Caroline, Zinner, Gabriel, Fürtges, Torben F., Narindoshvili, Tamari, Schindler, Sebastian, Bruckmann, Astrid
, Rudack, Till, Raushel, Frank M.
und Sterner, Reinhard
(2025)
Photocontrolling the Enantioselectivity of a Phosphotriesterase via Incorporation of a Light-Responsive Unnatural Amino Acid.
JACS Au 5 (2), S. 858-870.
Busch, Markus Richard
(2024)
Reconstruction of the Emergence of New Enzyme Functions by Protein Engineering: Examples From Secondary and Xenobiotic Metabolism.
Dissertation, Universität Regensburg.
Funke, Franziska Jasmin
(2024)
Mechanistic Analysis and Antibiotic Target Validation of Aminodeoxychorismate Synthase and Anthranilate Synthase.
Dissertation, Universität Regensburg.
Kinateder, Thomas
, Mayer, Carina, Nazet, Julian und Sterner, Reinhard
(2024)
Improving enzyme functional annotation by integrating in vitro and in silico approaches: The example of histidinol phosphate phosphatases.
Protein Science 33 (2).
Kinateder, Thomas
(2023)
Evolutionary Analysis and Functional Characterization of Different Histidinol Phosphate Phosphatases.
Dissertation, Universität Regensburg.
Klein, Thomas Michael
(2023)
RNA-Binding as a Potential Moonlighting Function of Metabolic Enzymes in Escherichia coli.
Dissertation, Universität Regensburg.
Kropp, Cosimo
(2023)
Understanding Archaea-type Ether Lipids - searching for new derivatives in Bacteria and Archaea, functional studies on Geranylgeranylglyceryl Phosphate Synthase.
Dissertation, Universität Regensburg.
, Archipowa, Nataliya, Kutta, Roger Jan, König, Burkhard
und Toste, F. Dean
(2023)
Hybrid Catalysts for Enantioselective Photo-Phosphoric Acid Catalysis.
The Journal of Organic Chemistry 88, S. 6509-6522.
Volltext nicht vorhanden.
Zinner, Gabriel
(2023)
Data archive of "Photo-Controlling Substrate Stereoselectivity of Phosphotriesterase via the Incorporation of a Light Responsive Non Canonical Amino Acid".
[Datensatz]
(2023)
Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli.
Biochemistry 62 (3), S. 863-872.
Volltext nicht vorhanden.
Kinateder, Thomas
, Drexler, Lukas, Straub, Kristina
, Merkl, Rainer
und Sterner, Reinhard
(2022)
Experimental and computational analysis of the ancestry of an evolutionary young enzyme from histidine biosynthesis.
Protein Science 32 (1), e4536.
Kneuttinger, Andrea C.
(2022)
A guide to designing photocontrol in proteins: methods, strategies and applications.
Biological Chemistry.
Hupfeld, Enrico
(2021)
Linkage between catalytic mechanism and conformational dynamics in (βα)₈-barrel enzymes at the example of Imidazole Glycerol Phosphate Synthase.
Dissertation, Universität Regensburg.
(2021)
In Silico Identification and Experimental Validation of Distal Activity-Enhancing Mutations in Tryptophan Synthase.
ACS Catalysis 11 (21), S. 13733-13743.
Volltext nicht vorhanden.
und Sterner, Reinhard
(2021)
Reprogramming the Specificity of a Protein Interface by Computational and Data-Driven Design.
Structure 29 (3), 292-304.e3.
Volltext nicht vorhanden.
Simeth, Nadja Anita
, Kinateder, Thomas, Rajendran, Chitra, Nazet, Julian, Merkl, Rainer
, Sterner, Reinhard
, König, Burkhard
und Kneuttinger, Andrea C.
(2020)
Towards Photochromic Azobenzene‐Based Inhibitors for Tryptophan Synthase.
Chemistry—A European Journal 27, S. 2439-2451.
, Busch, Florian, Schupfner, Michael, Sterner, Reinhard und Wysocki, Vicki H.
(2020)
Quaternary Structure of the Tryptophan Synthase α-Subunit Homolog BX1 from Zea mays.
Journal of the American Society for Mass Spectrometry 31 (2), S. 227-233.
Volltext nicht vorhanden.
, Rajendran, Chitra, Simeth, Nadja A., Bruckmann, Astrid, König, Burkhard
und Sterner, Reinhard
(2020)
Significance of the Protein Interface Configuration for Allostery in Imidazole Glycerol Phosphate Synthase.
Biochemistry 59 (29), S. 2729-2742.
Volltext nicht vorhanden.
Kneuttinger, Andrea C.
, Zwisele, Stefanie, Straub, Kristina
, Bruckmann, Astrid, Busch, Florian, Kinateder, Thomas, Gaim, Barbara, Wysocki, Vicki H.
, Merkl, Rainer
und Sterner, Reinhard
(2019)
Light-Regulation of Tryptophan Synthase by Combining Protein Design and Enzymology.
International Journal of Molecular Sciences 20 (20), S. 5106.
Semmelmannn, Florian
(2019)
Analysis of Allosteric Communication Pathways in Class I Glutamine Amidotransferases.
Dissertation, Universität Regensburg.
Schupfner, Michael
(2019)
Analysis of Allostery in the Tryptophan Synthase Complex by Horizontal and Vertical Approaches.
Dissertation, Universität Regensburg.
Straub, Kristina
(2019)
Ancestral Sequence Reconstruction: Methods and Applications.
Dissertation, Universität Regensburg.
Killian, Tobias Friedrich
(2019)
Development, characterization and synthesis of multi-specific proteins for targeted delivery of nucleic acids and nucleic acid derivatives.
Dissertation, Universität Regensburg.
Semmelmann, Florian, Hofferberth, John, Ruther, Joachim
und Sterner, Reinhard
(2019)
Mapping key amino acid residues for the epimerase efficiency and stereospecificity of the sex pheromone biosynthetic short-chain dehydrogenases/reductases of Nasonia.
Scientific Reports 9 (330), S. 1-7.
(2019)
A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases.
Biochemistry 58 (22), S. 2584-2588.
Volltext nicht vorhanden.
, Busch, Florian, Merkl, Rainer
und Sterner, Reinhard
(2019)
Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction.
Proceedings of the National Academy of Sciences 117 (1), S. 346-354.
Volltext nicht vorhanden.
, Malcicka, Miriama, Bruckmann, Astrid, Broschwitz, Bastian, Straub, Kristina, Merkl, Rainer, Monroig, Oscar, Sterner, Reinhard, Ruther, Joachim
und Ellers, Jacintha
(2019)
Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia.
Journal of Experimental Biology.
Volltext nicht vorhanden.
(2019)
Generation of a Stand‐Alone Tryptophan Synthase α‐Subunit by Mimicking an Evolutionary Blueprint.
ChemBioChem 20 (21), S. 2747-2751.
Volltext nicht vorhanden.
Kaiser, Wolfgang
(2018)
Biochemische Charakterisierung des YbiB-Proteins aus Escherichia coli und dessen Identifizierung als Nukleotidpyrophosphatase.
Dissertation, Universität Regensburg.
, Heyn, Kristina, Merkl, Rainer
, König, Burkhard
und Sterner, Reinhard
(2018)
Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand.
ChemBioChem.
Volltext nicht vorhanden.
, Schupfner, Michael, Busch, Florian, Baslé, Arnaud, Ehrmann, Alexander, Sterner, Reinhard
und Mayans, Olga
(2018)
Evolutionary Morphing of Tryptophan Synthase: Functional Mechanisms for the Enzymatic Channeling of Indole.
Journal of Molecular Biology 430 (24), S. 5066-5079.
Volltext nicht vorhanden.
, Steinhoff, Heinz-Jürgen
und Sterner, Reinhard
(2018)
Relationship of Catalysis and Active Site Loop Dynamics in the (βα)8-Barrel Enzyme Indole-3-glycerol Phosphate Synthase.
Biochemistry 57 (23), S. 3265-3277.
Volltext nicht vorhanden.
, Kreutz, Christoph
, Duchardt-Ferner, Elke und Wöhnert, Jens
(2018)
The structure of the SAM/SAH-binding riboswitch.
Nucleic Acids Research 47 (5), S. 2654-2665.
Volltext nicht vorhanden.
Fischer, Robert Andreas
(2017)
Untersuchung von Mykobakteriophagen-Lysinen als antimykobakterielle Wirkstoffe.
Dissertation, Universität Regensburg.
Linde, Mona
(2017)
Characterization of Enzymes Involved in the Synthesis and Processing of Ether Lipids in Archaea and Bacteria.
Dissertation, Universität Regensburg.
Merkl, Rainer, Löffler, Patrick
, Schmitz, Samuel, Hupfeld, Enrico und Sterner, Reinhard
(2017)
Rosetta:MSF: a modular framework for multi-state computational protein design.
PLOS Computational Biology 13 (6), e1005600.
Plach, Maximilian
(2017)
Evolution of substrate specificity and protein-protein interactions in three enzyme superfamilies.
Dissertation, Universität Regensburg.
Holinski, Alexandra
(2017)
Analysis of complex stability and allosteric interaction in the imidazole glycerol phosphate synthase complex.
Dissertation, Universität Regensburg.
Simeth, Nadja Anita
, Kneuttinger, Andrea C., Sterner, Reinhard und König, Burkhard
(2017)
Photochromic Coenzyme Q Derivatives: Switching Redox Potentials with Light.
Chemical Science 8, S. 6474-6483.
Ruther, Joachim, Hagström, Asa K., Brandstetter, Birgit, Hofferberth, John, Bruckmann, Astrid, Semmelmann, Florian, Fink, Michaela, Lowack, Helena, Laberer, Sabine, Niehuis, Oliver, Deutzmann, Rainer, Löfstedt, Christer und Sterner, Reinhard
(2016)
Epimerisation of chiral hydroxylactones by short-chain dehydrogenases/reductases accounts for sex pheromone evolution in Nasonia.
Scientific Reports 6 (34697), S. 1-13.
Busch, Florian
(2016)
Tryptophan synthase complexes: evolution, substrate specificity, and quaternary structure.
Dissertation, Universität Regensburg.
Merkl, Rainer, Plach, Maximilian G., Reisinger, Bernd und Sterner, Reinhard
(2016)
Long-Term Persistence of Bi-functionality Contributes to the Robustness of Microbial Life through Exaptation.
PLoS Genetics 12 (1), S. 1-14.
und Sterner, Reinhard
(2016)
Ancestral Tryptophan Synthase Reveals Functional Sophistication of Primordial Enzyme Complexes.
Cell Chemical Biology 23 (6), S. 709-715.
Volltext nicht vorhanden.
, Janda, Jan-Oliver, Merkl, Rainer
und Sterner, Reinhard
(2015)
Improving thermal and detergent stability of Bacillus stearothermophilus neopullulanase by rational enzyme design.
Protein Engineering, Design and Selection 28 (6), S. 147-151.
Volltext nicht vorhanden.
Peterhoff, David
(2014)
Systematic structural and functional characterization of the family of Geranylgeranylglyceryl Phosphate Synthase-like enzymes.
Dissertation, Universität Regensburg.
Reisinger, Bernd
(2014)
Mechanistic investigation of artificially designed, light regulation of naturally occurring, and characterization of ancestral (βα)8-barrel enzymes.
Dissertation, Universität Regensburg.
Sommer, Bettina, Waege, Ingrid, Pöllmann, David, Seitz, Tobias, Thomm, Michael, Sterner, Reinhard
und Hausner, Winfried
(2014)
Activation of a chimeric Rpb5/RpoH subunit using library selection.
Plos One 9.
, Schmid, Veronika, Rajendran, Chitra, Carstensen, Linn, Schlee, Sandra, Blanquart, Samuel, Merkl, Rainer
und Sterner, Reinhard
(2014)
Evidence for the Existence of Elaborate Enzyme Complexes in the Paleoarchean Era.
Journal of the American Chemical Society 136 (1), S. 122-129.
Volltext nicht vorhanden.
, König, Burkhard
und Sterner, Reinhard
(2014)
Exploiting Protein Symmetry To Design Light-Controllable Enzyme Inhibitors.
Angewandte Chemie International Edition 53, S. 595-598.
Volltext nicht vorhanden.
, Löffler, Patrick, Merkl, Rainer
und Sterner, Reinhard
(2014)
TrpB2 Enzymes are O-Phospho-l-serine Dependent Tryptophan Synthases.
Biochemistry 53 (38), S. 6078-6083.
Volltext nicht vorhanden.
Meier, Monika M.
(2013)
Reconstructing molecular evolution by changing substrate specificities within the amidohydrolase superfamily of enzymes.
Dissertation, Universität Regensburg.
Sperl, Josef
(2013)
Etablierung von enzymatischer Aktivität auf künstlich erzeugten (βα)8-Barrel Proteinen.
Dissertation, Universität Regensburg.
Schneider, Daniel
(2013)
Identifikation und funktionelle Charakterisierung von TrpD2, einer neuen Klasse nukleinsäurebindender Proteine.
Dissertation, Universität Regensburg.
(2013)
Kinetic Mechanism of Indole-3-glycerol Phosphate Synthase.
Biochemistry 52 (1), S. 132-142.
Volltext nicht vorhanden.
, Höcker, Birte, Sterner, Reinhard
und Raushel, Frank M.
(2013)
Molecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase Template.
Journal of the American Chemical Society 135 (31), S. 11670-11677.
Volltext nicht vorhanden.
Carstensen, Linn
(2012)
Conservation of the folding mechanism between a thermostable (βα)8-barrel enzyme, its evolutionary relatives, and ancestral precursors generated by protein design.
Dissertation, Universität Regensburg.
Scherzinger, Anna Sophie
(2012)
Entwicklung einer Methode der zufälligen Domänenkombination zur Optimierung von Peptidoglykan-Hydrolasen für die Anwendung im Lebensmittel am Beispiel von Listeria spp. mit anschließender Charakterisierung ausgewählter Proteine.
Dissertation, Universität Regensburg.
und Merkl, Rainer
(2012)
Experimental assessment of the importance of amino acid positions identified by an entropy-based correlation analysis of multiple sequence alignments.
Biochemistry.
Volltext nicht vorhanden.
, Razeto, Adelia, Häger, Michaela C., Sterner, Reinhard
und Wilmanns, Matthias
(2012)
Catalysis Uncoupling in a Glutamine Amidotransferase Bienzyme by Unblocking the Glutaminase Active Site.
Chemistry & Biology 19 (12), S. 1589-1599.
Volltext nicht vorhanden.
(2012)
Constitutively Active Glutaminase Variants Provide Insights into the Activation Mechanism of Anthranilate Synthase.
Biochemistry 51 (13), S. 2812-2818.
Volltext nicht vorhanden.
, Sterner, Reinhard
und Babinger, Patrick
(2012)
Dimerization determines substrate specificity of a bacterial prenyltransferase.
Chembiochem : a European journal of chemical biology 13 (9), S. 1297-1303.
Volltext nicht vorhanden.
, Telefoncu, A. und Sterner, R.
(2012)
Directed evolution of ( )8-barrel enzymes: establishing phosphoribosylanthranilate isomerisation activity on the scaffold of the tryptophan synthase -subunit.
Protein Engineering Design and Selection 25 (6), S. 285-293.
Volltext nicht vorhanden.
, Schmid, Franz-Xaver und Sterner, Reinhard
(2012)
Folding Mechanism of an Extremely Thermostable (βα)8-Barrel Enzyme: A High Kinetic Barrier Protects the Protein from Denaturation.
Biochemistry 51 (16), S. 3420-3432.
Volltext nicht vorhanden.
Guldan, Harald
(2011)
Nachweis Archaea-typischer Lipide in Bacteria über die Aufklärung der Funktion von AraM und PcrB aus Bacillus subtilis.
Dissertation, Universität Regensburg.
und Bocola, Marco
(2011)
A Fast and Precise Approach for Computational Saturation Mutagenesis and its Experimental Validation by Using an Artificial (βα)8-Barrel Protein.
ChemBioChem.
Volltext nicht vorhanden.
Dietrich, Susanne
(2011)
Mutationsanalyse und kinetische Untersuchungen zum Reaktionsmechanismus der Indolglycerinphosphat-Synthase aus Sulfolobus solfataricus.
Dissertation, Universität Regensburg.
Seitz, Tobias
(2011)
Erhöhung der Löslichkeit und Stabilität verschiedener Proteine durch rationales Design und gelenkte Evolution.
Dissertation, Universität Regensburg.
Ehrmann, Alexander
(2011)
Strukturelle Analyse neuartiger Tryptophan-Synthasen und funktionelle Charakterisierung ihrer Homologen.
Dissertation, Universität Regensburg.
(2011)
Related (βα)8‐Barrel Proteins in Histidine and Tryptophan Biosynthesis: A Paradigm to Study Enzyme Evolution.
ChemBioChem 12 (10), S. 1487-1494.
Volltext nicht vorhanden.
(2011)
Stabilization of a Metabolic Enzyme by Library Selection in Thermus thermophilus.
ChemBioChem 12 (10), S. 1581-1588.
Volltext nicht vorhanden.
und Sterner, Reinhard
(2010)
Computational and Experimental Evidence for the Evolution of a (βα)8-Barrel Protein from an Ancestral Quarter-Barrel Stabilised by Disulfide Bonds.
Journal of Molecular Biology 398 (5), S. 763-773.
Volltext nicht vorhanden.
, Ballschmiter, Meike, Tiefenbach, Klaus-Jürgen, Sterner, Reinhard
und Liebl, Wolfgang
(2010)
Hyperthermostable acetyl xylan esterase.
Microbial biotechnology 3 (1), S. 84-92.
Volltext nicht vorhanden.
und Brunner, Eike
(2010)
The interaction of ammonia and xenon with the imidazole glycerol phosphate synthase from Thermotoga maritima as detected by NMR spectroscopy.
Protein science : a publication of the Protein Society 19 (9), S. 1774-1782.
Volltext nicht vorhanden.
Claren, Jörg
(2009)
Design stabiler und katalytisch aktiver (beta, alpha)8-Barrel-Enzyme durch Rekombination von (beta, alpha)4-Halbbarrel-Domänen.
Dissertation, Universität Regensburg.
Richter, Markus
(2009)
Untersuchungen zur Evolution der (beta/alpha)8-barrel Faltung aus (beta/alpha)2-Modulen.
Dissertation, Universität Regensburg.
Forchheim, Michael
(2009)
Isolierung und Optimierung antimikrobiell wirkender Phagenproteine zur Bekämpfung antibiotikaresistenter Staphylokokken.
Dissertation, Universität Regensburg.
und Sterner, Reinhard
(2009)
Activation of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus by removal of magnesium inhibition and acceleration of product release.
Biochemistry 48 (23), S. 5199-209.
Volltext nicht vorhanden.
(2009)
Establishing wild-type levels of catalytic activity on natural and artificial (beta alpha)8-barrel protein scaffolds.
Proceedings of the National Academy of Sciences of the United States of America 106 (10), S. 3704-9.
Volltext nicht vorhanden.
, Fedorov, Alexander A., Meier, Monika M., Fedorov, Lena V., Nguyen, T. Tinh, Sterner, Reinhard
, Almo, Steven C., Shoichet, Brian K. und Raushel, Frank M.
(2009)
Functional annotation and three-dimensional structure of Dr0930 from Deinococcus radiodurans, a close relative of phosphotriesterase in the amidohydrolase superfamily.
Biochemistry 48 (10), S. 2237-47.
Volltext nicht vorhanden.
(2009)
High-resolution crystal structure of an artificial (betaalpha)(8)-barrel protein designed from identical half-barrels.
Biochemistry 48 (6), S. 1145-7.
Volltext nicht vorhanden.
Fischer, André, Enkler, Nils, Neudert, Gerd, Bocola, Marco, Sterner, Reinhard
und Merkl, Rainer
(2009)
TransCent: computational enzyme design by transferring active sites and considering constraints relevant for catalysis.
BMC Bioinformatics 10, S. 54.
Fischer, André
(2008)
TRANSCENT - ein Enzymdesignprogramm zum Transfer aktiver Zentren unter Wahrung Katalyse-relevanter Rahmenbedingungen.
Dissertation, Universität Regensburg.
und Sterner, Reinhard
(2008)
A rationally designed monomeric variant of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus is as active as the dimeric wild-type enzyme but less thermostable.
Journal of molecular biology 376 (2), S. 506-16.
Volltext nicht vorhanden.
, Mondière, Régis J. G., Dickmann, Norbert, Höcker, Birte, Cerrone, Simona, Haeger, Michaela C. und Sterner, Reinhard
(2008)
A robust protein host for anchoring chelating ligands and organocatalysts.
Chembiochem : a European journal of chemical biology 9 (4), S. 552-64.
Volltext nicht vorhanden.
und Babinger, Patrick
(2008)
Identification and characterization of a bacterial glycerol-1-phosphate dehydrogenase: Ni(2+)-dependent AraM from Bacillus subtilis.
Biochemistry 47 (28), S. 7376-84.
Volltext nicht vorhanden.
Deuß, Miriam
(2007)
Untersuchungen zur Struktur, Funktion und Dynamik der Anthranilat-Phosphoribosyltransferase aus Sulfolobus solfataricus.
Dissertation, Universität Regensburg.
Häger, Michaela C.
(2006)
Evolution und Regulation von Protein-Protein Interaktionen in zwei Glutamin-Amidotransferasen aus der Biosynthese von Histidin und Tryptophan.
Dissertation, Universität Regensburg.
Giesecke, Astrid
(2006)
Protein-protein interactions mediated by Cys2His2 zinc-fingers.
Dissertation, Universität Regensburg.
Leopoldseder, Sonja
(2006)
Neuartige Tryptophan-Synthasen aus Hyperthermophilen: Charakterisierung der Enzyme aus Sulfolobus solfataricus.
Dissertation, Universität Regensburg.
, Konarev, Petr V., Sterner, Reinhard
und Mayans, Olga
(2006)
Structural and Mutational Analysis of Substrate Complexation by Anthranilate Phosphoribosyltransferase from Sulfolobus solfataricus.
The Journal of Biological Chemistry 281 (30), S. 21410-21421.
Zugang zum Volltext eingeschränkt.
(2006)
Evolution of multi-enzyme complexes: the case of tryptophan synthase.
Biochemistry 45 (47), S. 14111-9.
Volltext nicht vorhanden.
(2005)
Catalytic versatility, stability, and evolution of the (betaalpha)8-barrel enzyme fold.
Chemical reviews 105 (11), S. 4038-55.
Volltext nicht vorhanden.
(2005)
Role of the N-terminal extension of the (betaalpha)8-barrel enzyme indole-3-glycerol phosphate synthase for its fold, stability, and catalytic activity.
Biochemistry 44 (50), S. 16405-12.
Volltext nicht vorhanden.
, Claren, Jörg und Sterner, Reinhard
(2004)
Mimicking enzyme evolution by generating new (betaalpha)8-barrels from (betaalpha)4-half-barrels.
Proceedings of the National Academy of Sciences of the United States of America 101 (47), S. 16448-53.
Volltext nicht vorhanden.
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