Bibliography of the Universität Regensburg

University of Regensburg (175)
- Biology, Preclinical Medicine (175)
  - Institut für Biophysik und physikalische Biochemie (175)
    - Prof. Dr. Reinhard Sterner (175)

Group by: Date | Creators | Item type | No Grouping

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Number of items at this level: 175.

2025

Kinateder, Thomas

, Drexler, Lukas, Duran, Cristina, Osuna, Sílvia and Sterner, Reinhard

(2025) A naturally occurring standalone TrpB enzyme provides insights into allosteric communication within tryptophan synthase. Protein Science 34 (4), e70103.

Hiefinger, Caroline, Zinner, Gabriel, Fürtges, Torben F., Narindoshvili, Tamari, Schindler, Sebastian

, Bruckmann, Astrid

, Rudack, Till

, Raushel, Frank M.

and Sterner, Reinhard

(2025) Photocontrolling the Enantioselectivity of a Phosphotriesterase via Incorporation of a Light-Responsive Unnatural Amino Acid. JACS Au 5 (2), pp. 858-870.

Hiefinger, Caroline, Zinner, Gabriel, Fürtges, Torben F., Narindoshvili, Tamari, Schindler, Sebastian, Bruckmann, Astrid

, Rudack, Till, Raushel, Frank M.

and Sterner, Reinhard

(2025) Photocontrolling the Enantioselectivity of a Phosphotriesterase via Incorporation of a Light-Responsive Unnatural Amino Acid. JACS Au 5 (2), pp. 858-870.

2024

Busch, Markus Richard (2024) Reconstruction of the Emergence of New Enzyme Functions by Protein Engineering: Examples From Secondary and Xenobiotic Metabolism. PhD, Universität Regensburg.

Funke, Franziska Jasmin

(2024) Mechanistic Analysis and Antibiotic Target Validation of Aminodeoxychorismate Synthase and Anthranilate Synthase. PhD, Universität Regensburg.

Kinateder, Thomas

, Mayer, Carina, Nazet, Julian and Sterner, Reinhard

(2024) Improving enzyme functional annotation by integrating in vitro and in silico approaches: The example of histidinol phosphate phosphatases. Protein Science 33 (2).

2023

Kinateder, Thomas

(2023) Evolutionary Analysis and Functional Characterization of Different Histidinol Phosphate Phosphatases. PhD, Universität Regensburg.

Klein, Thomas Michael (2023) RNA-Binding as a Potential Moonlighting Function of Metabolic Enzymes in Escherichia coli. PhD, Universität Regensburg.

Kropp, Cosimo (2023) Understanding Archaea-type Ether Lipids - searching for new derivatives in Bacteria and Archaea, functional studies on Geranylgeranylglyceryl Phosphate Synthase. PhD, Universität Regensburg.

Rolka, Alessa B.

, Archipowa, Nataliya, Kutta, Roger Jan, König, Burkhard

and Toste, F. Dean (2023) Hybrid Catalysts for Enantioselective Photo-Phosphoric Acid Catalysis. The Journal of Organic Chemistry 88, pp. 6509-6522. Fulltext not available.

Zinner, Gabriel (2023) Data archive of "Photo-Controlling Substrate Stereoselectivity of Phosphotriesterase via the Incorporation of a Light Responsive Non Canonical Amino Acid". [Dataset]

Archipowa, Nataliya, Wittmann, Lukas, Köckenberger, Johannes, Ertl, Fabian J., Gleixner, Jakob, Keller, Max, Heinrich, Markus R. and Kutta, Roger Jan (2023) Characterization of Fluorescent Dyes Frequently Used for Bioimaging: Photophysics and Photocatalytical Reactions with Proteins. The Journal of Physical Chemistry B 127 (44), pp. 9532-9542. Fulltext not available.

Busch, Markus R., Drexler, Lukas, Mahato, Dhani Ram, Hiefinger, Caroline, Osuna, Sílvia and Sterner, Reinhard (2023) Retracing the Rapid Evolution of an Herbicide-Degrading Enzyme by Protein Engineering. ACS Catalysis 13 (23), pp. 15558-15571. Fulltext not available.

Busch, Markus R., Rajendran, Chitra and Sterner, Reinhard

(2023) Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli. Biochemistry 62 (3), pp. 863-872. Fulltext not available.

2022

Kinateder, Thomas

, Drexler, Lukas, Straub, Kristina

, Merkl, Rainer

and Sterner, Reinhard

(2022) Experimental and computational analysis of the ancestry of an evolutionary young enzyme from histidine biosynthesis. Protein Science 32 (1), e4536.

Kneuttinger, Andrea C.

(2022) A guide to designing photocontrol in proteins: methods, strategies and applications. Biological Chemistry.

Bhagat, Ashok Kumar, Schlee, Sandra, Straub, Kristina, Nazet, Julian, Luckner, Patricia, Bruckmann, Astrid and Sterner, Reinhard (2022) Photoswitching of Feedback Inhibition by Tryptophan in Anthranilate Synthase. ACS Synthetic Biology 11 (8), pp. 2846-2856. Fulltext not available.

2021

Hupfeld, Enrico (2021) Linkage between catalytic mechanism and conformational dynamics in (βα)₈-barrel enzymes at the example of Imidazole Glycerol Phosphate Synthase. PhD, Universität Regensburg.

Maria-Solano, Miguel A., Kinateder, Thomas, Iglesias-Fernández, Javier, Sterner, Reinhard and Osuna, Sílvia

(2021) In Silico Identification and Experimental Validation of Distal Activity-Enhancing Mutations in Tryptophan Synthase. ACS Catalysis 11 (21), pp. 13733-13743. Fulltext not available.

Hertle, Regina, Nazet, Julian, Semmelmann, Florian, Schlee, Sandra, Funke, Franziska, Merkl, Rainer

and Sterner, Reinhard (2021) Reprogramming the Specificity of a Protein Interface by Computational and Data-Driven Design. Structure 29 (3), 292-304.e3. Fulltext not available.

2020

Simeth, Nadja Anita

, Kinateder, Thomas, Rajendran, Chitra, Nazet, Julian, Merkl, Rainer

, Sterner, Reinhard

, König, Burkhard

and Kneuttinger, Andrea C.

(2020) Towards Photochromic Azobenzene‐Based Inhibitors for Tryptophan Synthase. Chemistry—A European Journal 27, pp. 2439-2451.

Norris, Andrew

, Busch, Florian, Schupfner, Michael, Sterner, Reinhard and Wysocki, Vicki H. (2020) Quaternary Structure of the Tryptophan Synthase α-Subunit Homolog BX1 from Zea mays. Journal of the American Society for Mass Spectrometry 31 (2), pp. 227-233. Fulltext not available.

Kneuttinger, Andrea C.

, Rajendran, Chitra, Simeth, Nadja A., Bruckmann, Astrid, König, Burkhard

and Sterner, Reinhard

(2020) Significance of the Protein Interface Configuration for Allostery in Imidazole Glycerol Phosphate Synthase. Biochemistry 59 (29), pp. 2729-2742. Fulltext not available.

2019

Kneuttinger, Andrea C.

, Zwisele, Stefanie, Straub, Kristina

, Bruckmann, Astrid, Busch, Florian, Kinateder, Thomas, Gaim, Barbara, Wysocki, Vicki H.

, Merkl, Rainer

and Sterner, Reinhard (2019) Light-Regulation of Tryptophan Synthase by Combining Protein Design and Enzymology. International Journal of Molecular Sciences 20 (20), p. 5106.

Semmelmannn, Florian (2019) Analysis of Allosteric Communication Pathways in Class I Glutamine Amidotransferases. PhD, Universität Regensburg.

Schupfner, Michael (2019) Analysis of Allostery in the Tryptophan Synthase Complex by Horizontal and Vertical Approaches. PhD, Universität Regensburg.

Straub, Kristina

(2019) Ancestral Sequence Reconstruction: Methods and Applications. PhD, Universität Regensburg.

Killian, Tobias Friedrich (2019) Development, characterization and synthesis of multi-specific proteins for targeted delivery of nucleic acids and nucleic acid derivatives. PhD, Universität Regensburg.

Semmelmann, Florian, Hofferberth, John, Ruther, Joachim

and Sterner, Reinhard

(2019) Mapping key amino acid residues for the epimerase efficiency and stereospecificity of the sex pheromone biosynthetic short-chain dehydrogenases/reductases of Nasonia. Scientific Reports 9 (330), pp. 1-7.

Semmelmann, Florian, Hupfeld, Enrico, Heizinger, Leonhard, Merkl, Rainer and Sterner, Reinhard

(2019) A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases. Biochemistry 58 (22), pp. 2584-2588. Fulltext not available.

Schupfner, Michael, Straub, Kristina

, Busch, Florian, Merkl, Rainer

and Sterner, Reinhard

(2019) Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction. Proceedings of the National Academy of Sciences 117 (1), pp. 346-354. Fulltext not available.

Semmelmann, Florian, Kabeya, Naoki

, Malcicka, Miriama, Bruckmann, Astrid, Broschwitz, Bastian, Straub, Kristina, Merkl, Rainer, Monroig, Oscar, Sterner, Reinhard, Ruther, Joachim

and Ellers, Jacintha

(2019) Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia. Journal of Experimental Biology. Fulltext not available.

Schupfner, Michael, Busch, Florian, Wysocki, Vicki H. and Sterner, Reinhard

(2019) Generation of a Stand‐Alone Tryptophan Synthase α‐Subunit by Mimicking an Evolutionary Blueprint. ChemBioChem 20 (21), pp. 2747-2751. Fulltext not available.

2018

Kaiser, Wolfgang (2018) Biochemische Charakterisierung des YbiB-Proteins aus Escherichia coli und dessen Identifizierung als Nukleotidpyrophosphatase. PhD, Universität Regensburg.

Kneuttinger, Andrea C., Winter, Martin, Simeth, Nadja Anita

, Heyn, Kristina, Merkl, Rainer

, König, Burkhard

and Sterner, Reinhard

(2018) Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand. ChemBioChem. Fulltext not available.

Fleming, Jennifer R.

, Schupfner, Michael, Busch, Florian, Baslé, Arnaud, Ehrmann, Alexander, Sterner, Reinhard

and Mayans, Olga

(2018) Evolutionary Morphing of Tryptophan Synthase: Functional Mechanisms for the Enzymatic Channeling of Indole. Journal of Molecular Biology 430 (24), pp. 5066-5079. Fulltext not available.

Schlee, Sandra, Klein, Thomas, Schumacher, Magdalena, Nazet, Julian, Merkl, Rainer

, Steinhoff, Heinz-Jürgen

and Sterner, Reinhard

(2018) Relationship of Catalysis and Active Site Loop Dynamics in the (βα)8-Barrel Enzyme Indole-3-glycerol Phosphate Synthase. Biochemistry 57 (23), pp. 3265-3277. Fulltext not available.

Weickhmann, A. Katharina, Keller, Heiko, Wurm, Jan P., Strebitzer, Elisabeth, Juen, Michael A., Kremser, Johannes, Weinberg, Zasha

, Kreutz, Christoph

, Duchardt-Ferner, Elke and Wöhnert, Jens (2018) The structure of the SAM/SAH-binding riboswitch. Nucleic Acids Research 47 (5), pp. 2654-2665. Fulltext not available.

2017

Fischer, Robert Andreas (2017) Untersuchung von Mykobakteriophagen-Lysinen als antimykobakterielle Wirkstoffe. PhD, Universität Regensburg.

Linde, Mona (2017) Characterization of Enzymes Involved in the Synthesis and Processing of Ether Lipids in Archaea and Bacteria. PhD, Universität Regensburg.

Merkl, Rainer, Löffler, Patrick

, Schmitz, Samuel, Hupfeld, Enrico and Sterner, Reinhard

(2017) Rosetta:MSF: a modular framework for multi-state computational protein design. PLOS Computational Biology 13 (6), e1005600.

Plach, Maximilian (2017) Evolution of substrate specificity and protein-protein interactions in three enzyme superfamilies. PhD, Universität Regensburg.

Holinski, Alexandra (2017) Analysis of complex stability and allosteric interaction in the imidazole glycerol phosphate synthase complex. PhD, Universität Regensburg.

Sterner, Reinhard, Höcker, Birte and Kolmar, Harald (2017) Highlight issue: protein design. Biological Chemistry 398 (1), pp. 1-2. Fulltext not available.

Simeth, Nadja Anita

, Kneuttinger, Andrea C., Sterner, Reinhard and König, Burkhard

(2017) Photochromic Coenzyme Q Derivatives: Switching Redox Potentials with Light. Chemical Science 8, pp. 6474-6483.

2016

Ruther, Joachim, Hagström, Asa K., Brandstetter, Birgit, Hofferberth, John, Bruckmann, Astrid, Semmelmann, Florian, Fink, Michaela, Lowack, Helena, Laberer, Sabine, Niehuis, Oliver, Deutzmann, Rainer, Löfstedt, Christer and Sterner, Reinhard (2016) Epimerisation of chiral hydroxylactones by short-chain dehydrogenases/reductases accounts for sex pheromone evolution in Nasonia. Scientific Reports 6 (34697), pp. 1-13.

Busch, Florian (2016) Tryptophan synthase complexes: evolution, substrate specificity, and quaternary structure. PhD, Universität Regensburg.

Merkl, Rainer, Plach, Maximilian G., Reisinger, Bernd and Sterner, Reinhard

(2016) Long-Term Persistence of Bi-functionality Contributes to the Robustness of Microbial Life through Exaptation. PLoS Genetics 12 (1), pp. 1-14.

Busch, Florian, Rajendran, Chitra, Heyn, Kristina, Schlee, Sandra, Merkl, Rainer

and Sterner, Reinhard (2016) Ancestral Tryptophan Synthase Reveals Functional Sophistication of Primordial Enzyme Complexes. Cell Chemical Biology 23 (6), pp. 709-715. Fulltext not available.

2015

Ece, Selin, Evran, Serap

, Janda, Jan-Oliver, Merkl, Rainer

and Sterner, Reinhard

(2015) Improving thermal and detergent stability of Bacillus stearothermophilus neopullulanase by rational enzyme design. Protein Engineering, Design and Selection 28 (6), pp. 147-151. Fulltext not available.

2014

Peterhoff, David (2014) Systematic structural and functional characterization of the family of Geranylgeranylglyceryl Phosphate Synthase-like enzymes. PhD, Universität Regensburg.

Reisinger, Bernd (2014) Mechanistic investigation of artificially designed, light regulation of naturally occurring, and characterization of ancestral (βα)8-barrel enzymes. PhD, Universität Regensburg.

Sommer, Bettina, Waege, Ingrid, Pöllmann, David, Seitz, Tobias, Thomm, Michael, Sterner, Reinhard

and Hausner, Winfried (2014) Activation of a chimeric Rpb5/RpoH subunit using library selection. Plos One 9.

Reisinger, Bernd, Sperl, Josef, Holinski, Alexandra

, Schmid, Veronika, Rajendran, Chitra, Carstensen, Linn, Schlee, Sandra, Blanquart, Samuel, Merkl, Rainer

and Sterner, Reinhard

(2014) Evidence for the Existence of Elaborate Enzyme Complexes in the Paleoarchean Era. Journal of the American Chemical Society 136 (1), pp. 122-129. Fulltext not available.

Reisinger, Bernd, Kuzmanovic, Natascha, Löffler, Patrick, Merkl, Rainer

, König, Burkhard

and Sterner, Reinhard

(2014) Exploiting Protein Symmetry To Design Light-Controllable Enzyme Inhibitors. Angewandte Chemie International Edition 53, pp. 595-598. Fulltext not available.

Busch, Florian, Rajendran, Chitra, Mayans, Olga

, Löffler, Patrick, Merkl, Rainer

and Sterner, Reinhard

(2014) TrpB2 Enzymes are O-Phospho-l-serine Dependent Tryptophan Synthases. Biochemistry 53 (38), pp. 6078-6083. Fulltext not available.

2013

Meier, Monika M. (2013) Reconstructing molecular evolution by changing substrate specificities within the amidohydrolase superfamily of enzymes. PhD, Universität Regensburg.

Sperl, Josef (2013) Etablierung von enzymatischer Aktivität auf künstlich erzeugten (βα)8-Barrel Proteinen. PhD, Universität Regensburg.

Schneider, Daniel (2013) Identifikation und funktionelle Charakterisierung von TrpD2, einer neuen Klasse nukleinsäurebindender Proteine. PhD, Universität Regensburg.

Sperl, Josef M., Rohweder, Bettina, Rajendran, Chitra and Sterner, Reinhard (2013) Establishing catalytic activity on an artificial (βα)8‐barrel protein designed from identical half‐barrels. FEBS Letters 587 (17), pp. 2798-2805. Fulltext not available.

Schlee, Sandra, Dietrich, Susanne, Kurćon, Tomasz, Delaney, Pamela, Goodey, Nina M. and Sterner, Reinhard

(2013) Kinetic Mechanism of Indole-3-glycerol Phosphate Synthase. Biochemistry 52 (1), pp. 132-142. Fulltext not available.

Meier, Monika M., Rajendran, Chitra, Malisi, Christoph, Fox, Nicholas G., Xu, Chengfu, Schlee, Sandra, Barondeau, David P.

, Höcker, Birte, Sterner, Reinhard

and Raushel, Frank M.

(2013) Molecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase Template. Journal of the American Chemical Society 135 (31), pp. 11670-11677. Fulltext not available.

2012

Carstensen, Linn (2012) Conservation of the folding mechanism between a thermostable (βα)8-barrel enzyme, its evolutionary relatives, and ancestral precursors generated by protein design. PhD, Universität Regensburg.

Scherzinger, Anna Sophie (2012) Entwicklung einer Methode der zufälligen Domänenkombination zur Optimierung von Peptidoglykan-Hydrolasen für die Anwendung im Lebensmittel am Beispiel von Listeria spp. mit anschließender Charakterisierung ausgewählter Proteine. PhD, Universität Regensburg.

Dietrich, Susanne, Borst, Nadine, Schlee, Sandra, Schneider, Daniel, Janda, Jan-Oliver, Sterner, Reinhard

and Merkl, Rainer

(2012) Experimental assessment of the importance of amino acid positions identified by an entropy-based correlation analysis of multiple sequence alignments. Biochemistry. Fulltext not available.

Reisinger, B., Bocola, M., List, F., Claren, J., Rajendran, C. and Sterner, R. (2012) A sugar isomerization reaction established on various ( )8-barrel scaffolds is based on substrate-assisted catalysis. Protein Engineering Design and Selection 25 (11), pp. 751-760. Fulltext not available.

List, Felix, Vega, M. Cristina

, Razeto, Adelia, Häger, Michaela C., Sterner, Reinhard

and Wilmanns, Matthias

(2012) Catalysis Uncoupling in a Glutamine Amidotransferase Bienzyme by Unblocking the Glutaminase Active Site. Chemistry & Biology 19 (12), pp. 1589-1599. Fulltext not available.

Carstensen, Linn, Sperl, Josef M., Bocola, Marco, List, Felix, Schmid, Franz X. and Sterner, Reinhard (2012) Conservation of the Folding Mechanism between Designed Primordial (βα)8-Barrel Proteins and Their Modern Descendant. Journal of the American Chemical Society 134 (30), pp. 12786-12791. Fulltext not available.

List, Felix, Bocola, Marco, Haeger, Michaela C. and Sterner, Reinhard

(2012) Constitutively Active Glutaminase Variants Provide Insights into the Activation Mechanism of Anthranilate Synthase. Biochemistry 51 (13), pp. 2812-2818. Fulltext not available.

Peterhoff, David, Zellner, Hermann, Guldan, Harald, Merkl, Rainer

, Sterner, Reinhard

and Babinger, Patrick

(2012) Dimerization determines substrate specificity of a bacterial prenyltransferase. Chembiochem : a European journal of chemical biology 13 (9), pp. 1297-1303. Fulltext not available.

Evran, S.

, Telefoncu, A. and Sterner, R. (2012) Directed evolution of ( )8-barrel enzymes: establishing phosphoribosylanthranilate isomerisation activity on the scaffold of the tryptophan synthase -subunit. Protein Engineering Design and Selection 25 (6), pp. 285-293. Fulltext not available.

Carstensen, Linn, Zoldák, Gabriel

, Schmid, Franz-Xaver and Sterner, Reinhard (2012) Folding Mechanism of an Extremely Thermostable (βα)8-Barrel Enzyme: A High Kinetic Barrier Protects the Protein from Denaturation. Biochemistry 51 (16), pp. 3420-3432. Fulltext not available.

Craig, Douglas B., Schwab, Thomas and Sterner, Reinhard (2012) Random mutagenesis suggests that sequence errors are not a major cause of variation in the activity of individual molecules of β-galactosidase. Biochemistry and Cell Biology 90 (4), pp. 540-547. Fulltext not available.

2011

Guldan, Harald (2011) Nachweis Archaea-typischer Lipide in Bacteria über die Aufklärung der Funktion von AraM und PcrB aus Bacillus subtilis. PhD, Universität Regensburg.

Fischer, André, Seitz, Tobias, Lochner, Adriane, Sterner, Reinhard, Merkl, Rainer

and Bocola, Marco (2011) A Fast and Precise Approach for Computational Saturation Mutagenesis and its Experimental Validation by Using an Artificial (βα)8-Barrel Protein. ChemBioChem. Fulltext not available.

Dietrich, Susanne (2011) Mutationsanalyse und kinetische Untersuchungen zum Reaktionsmechanismus der Indolglycerinphosphat-Synthase aus Sulfolobus solfataricus. PhD, Universität Regensburg.

Seitz, Tobias (2011) Erhöhung der Löslichkeit und Stabilität verschiedener Proteine durch rationales Design und gelenkte Evolution. PhD, Universität Regensburg.

Ehrmann, Alexander (2011) Strukturelle Analyse neuartiger Tryptophan-Synthasen und funktionelle Charakterisierung ihrer Homologen. PhD, Universität Regensburg.

List, Felix, Sterner, Reinhard and Wilmanns, Matthias

(2011) Related (βα)8‐Barrel Proteins in Histidine and Tryptophan Biosynthesis: A Paradigm to Study Enzyme Evolution. ChemBioChem 12 (10), pp. 1487-1494. Fulltext not available.

Schwab, Thomas and Sterner, Reinhard

(2011) Stabilization of a Metabolic Enzyme by Library Selection in Thermus thermophilus. ChemBioChem 12 (10), pp. 1581-1588. Fulltext not available.

2010

Burghardt, Kathleen (2010) Aktivierung einer thermostabilen Anthranilat-Phosphoribosyltransferase durch gerichtete Evolution. Diplomarbeit, Universität Regensburg. Fulltext not available.

Richter, Markus, Bosnali, Manal, Carstensen, Linn, Seitz, Tobias, Durchschlag, Helmut, Blanquart, Samuel, Merkl, Rainer

and Sterner, Reinhard

(2010) Computational and Experimental Evidence for the Evolution of a (βα)8-Barrel Protein from an Ancestral Quarter-Barrel Stabilised by Disulfide Bonds. Journal of Molecular Biology 398 (5), pp. 763-773. Fulltext not available.

Seitz, Tobias, Thoma, Ralf, Schoch, Guillaume A., Stihle, Martine, Benz, Jörg, D'Arcy, Brigitte, Wiget, Andrea, Ruf, Armin, Hennig, Michael and Sterner, Reinhard (2010) Enhancing the stability and solubility of the glucocorticoid receptor ligand-binding domain by high-throughput library screening. Journal of molecular biology 403 (4), pp. 562-577. Fulltext not available.

Borst, Nadine (2010) Experimentelle Validierung von durch bioinformatische Korrelationsanalysen identifizierten Aminosäurepositionen. Diplomarbeit, UNSPECIFIED. Fulltext not available.

Busch, Florian (2010) Funktionsaufklärung des zur Tryptophansynthese homologen Enzyms sTrpBs2. Diplomarbeit, UNSPECIFIED. Fulltext not available.

Drzewiecki, Katharina, Angelov, Angel

, Ballschmiter, Meike, Tiefenbach, Klaus-Jürgen, Sterner, Reinhard

and Liebl, Wolfgang

(2010) Hyperthermostable acetyl xylan esterase. Microbial biotechnology 3 (1), pp. 84-92. Fulltext not available.

Ehrmann, Alexander, Richter, Klaus, Busch, Florian, Reimann, Julia, Albers, Sonja-Verena and Sterner, Reinhard (2010) Ligand-induced formation of a transient tryptophan synthase complex with aßß subunit stoichiometry. Biochemistry 49 (51), pp. 10842-10853. Fulltext not available.

Dietrich, Susanne (2010) Mutationsanalyse und kinetische Untersuchungen zum Reaktionsmechanismus der Indolglycerinphosphat-Synthase aus Sulfolobus solfataricus. PhD, Universität Regensburg. Fulltext not available.

Liebold, Christoph, List, Felix, Kalbitzer, Hans Robert, Sterner, Reinhard

and Brunner, Eike (2010) The interaction of ammonia and xenon with the imidazole glycerol phosphate synthase from Thermotoga maritima as detected by NMR spectroscopy. Protein science : a publication of the Protein Society 19 (9), pp. 1774-1782. Fulltext not available.

2009

Claren, Jörg (2009) Design stabiler und katalytisch aktiver (beta, alpha)8-Barrel-Enzyme durch Rekombination von (beta, alpha)4-Halbbarrel-Domänen. PhD, Universität Regensburg.

Richter, Markus (2009) Untersuchungen zur Evolution der (beta/alpha)8-barrel Faltung aus (beta/alpha)2-Modulen. PhD, Universität Regensburg.

Forchheim, Michael (2009) Isolierung und Optimierung antimikrobiell wirkender Phagenproteine zur Bekämpfung antibiotikaresistenter Staphylokokken. PhD, Universität Regensburg.

Schlee, Sandra, Deuss, Miriam, Bruning, Marc, Ivens, Andreas, Schwab, Thomas, Hellmann, Nadja, Mayans, Olga

and Sterner, Reinhard

(2009) Activation of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus by removal of magnesium inhibition and acceleration of product release. Biochemistry 48 (23), pp. 5199-209. Fulltext not available.

Sommer, Bettina (2009) Aktivierung einer chimären RNA-Polymerase Untereinheit durch gerichtete Evoluton. Diplomarbeit, Universität Regensburg. Fulltext not available.

Sperl, Josef (2009) Analyse der Faltung und Erhöhung der Stabilität künstlich erzeugter (βα)₈-Barrel Proteine. Diplomarbeit, Universität Regensburg. Fulltext not available.

List, Felix (2009) Die Imidazolglycerinphosphat-Synthase aus Thermotoga Maritima: Struktur, Regulation und Evolution einer Glutaminamidotransferase. PhD, Universität Regensburg. Fulltext not available.

Roderer, Daniel (2009) Die Suche nach Interaktionspartnern des uncharakterisierten E.coli -Proteins YbiB. Diplomarbeit, Universität Regensburg. Fulltext not available.

Esslinger, Ulrike (2009) Die uncharakterisierte Proteingruppe COG0325: Funktionsaufklärung und Suche nach Interaktionspartnern. Diplomarbeit, Universität Regensburg. Fulltext not available.

Peterhoff, David (2009) Einbau nichtnatürlicher Aminosäuren zur Untersuchung der Dimerisierung von PcrB. Diplomarbeit, Universität Regensburg. Fulltext not available.

Claren, Jörg, Malisi, Christoph, Höcker, Birte and Sterner, Reinhard

(2009) Establishing wild-type levels of catalytic activity on natural and artificial (beta alpha)8-barrel protein scaffolds. Proceedings of the National Academy of Sciences of the United States of America 106 (10), pp. 3704-9. Fulltext not available.

Reisinger, Bernd (2009) Experimentelle Charakterisierung bzw. Verbesserung von rational designten (βα)₈-Barrel Proteinen aus dem Histidinbiosyntheseweg. Diplomarbeit, Universität Regensburg. Fulltext not available.

Xiang, Dao Feng, Kolb, Peter

, Fedorov, Alexander A., Meier, Monika M., Fedorov, Lena V., Nguyen, T. Tinh, Sterner, Reinhard

, Almo, Steven C., Shoichet, Brian K. and Raushel, Frank M.

(2009) Functional annotation and three-dimensional structure of Dr0930 from Deinococcus radiodurans, a close relative of phosphotriesterase in the amidohydrolase superfamily. Biochemistry 48 (10), pp. 2237-47. Fulltext not available.

Höcker, Birte, Lochner, Adriane, Seitz, Tobias, Claren, Jörg and Sterner, Reinhard

(2009) High-resolution crystal structure of an artificial (betaalpha)(8)-barrel protein designed from identical half-barrels. Biochemistry 48 (6), pp. 1145-7. Fulltext not available.

Fischer, André, Enkler, Nils, Neudert, Gerd, Bocola, Marco, Sterner, Reinhard

and Merkl, Rainer

(2009) TransCent: computational enzyme design by transferring active sites and considering constraints relevant for catalysis. BMC Bioinformatics 10, p. 54.

2008

Fischer, André (2008) TRANSCENT - ein Enzymdesignprogramm zum Transfer aktiver Zentren unter Wahrung Katalyse-relevanter Rahmenbedingungen. PhD, Universität Regensburg.

Schwab, Thomas, Skegro, Darko, Mayans, Olga

and Sterner, Reinhard

(2008) A rationally designed monomeric variant of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus is as active as the dimeric wild-type enzyme but less thermostable. Journal of molecular biology 376 (2), pp. 506-16. Fulltext not available.

Reetz, Manfred T., Rentzsch, Martin, Pletsch, Andreas, Taglieber, Andreas, Hollmann, Frank

, Mondière, Régis J. G., Dickmann, Norbert, Höcker, Birte, Cerrone, Simona, Haeger, Michaela C. and Sterner, Reinhard

(2008) A robust protein host for anchoring chelating ligands and organocatalysts. Chembiochem : a European journal of chemical biology 9 (4), pp. 552-64. Fulltext not available.

Sterner, Reinhard, Merkl, Rainer and Raushel, Frank M. (2008) Computational design of enzymes. Chemistry & Biology 15 (5), pp. 421-423. Fulltext not available.

Sterner, Reinhard, Merkl, Rainer and Raushel, Frank M. (2008) Computational design of enzymes. Chemistry & biology 15 (5), pp. 421-3. Fulltext not available.

Guldan, Harald, Sterner, Reinhard

and Babinger, Patrick

(2008) Identification and characterization of a bacterial glycerol-1-phosphate dehydrogenase: Ni(2+)-dependent AraM from Bacillus subtilis. Biochemistry 47 (28), pp. 7376-84. Fulltext not available.

Meier, Monika (2008) Interconversion of Substrate Specificity within the Amidohydrolase Superfamily of Enzymes. Diplomarbeit, Universität Regensburg. Fulltext not available.

Lochner, Adriane (2008) Stabilisierung und Aktivierung eines künstlichen (βα)₈ Fass Proteins. Diplomarbeit, Universität Regensburg. Fulltext not available.

2007

Deuß, Miriam (2007) Untersuchungen zur Struktur, Funktion und Dynamik der Anthranilat-Phosphoribosyltransferase aus Sulfolobus solfataricus. PhD, Universität Regensburg.

Guldan, Harald (2007) Charakterisierung der sn-Glycerin-1-Phosphat-abhängigen Enzyme AraM und PcrB aus Bacillus subtilis. Diplomarbeit, Universität Regensburg. Fulltext not available.

Schneider, Daniel (2007) Charakterisierung von ybiB, einer putativen Phosphoribosyltransferase aus Escherichia coli. Diplomarbeit, Universität Regensburg. Fulltext not available.

Schwabe, Anne (2007) Mutationsanalysen der Komplexbildung von Tryptophan-Synthasen aus Thermotoga maritima. Diplomarbeit, Universität Regensburg. Fulltext not available.

Zwick, Matthias (2007) Rekombinante Expression der Bacillus subtilis Gene pabA, pabB und trpE und Charakterisierung der Komplexbildung der Genprodukte. Diplomarbeit, Universität Regensburg. Fulltext not available.

Seitz, Tobias, Bocola, Marco, Claren, Jörg and Sterner, Reinhard (2007) Stabilisation of a (betaalpha)8-barrel protein designed from identical half barrels. Journal of molecular biology 372 (1), pp. 114-29. Fulltext not available.

Einhell, Sabine (2007) Stabilisierung von Noc4D6-8 aus Saccharomyces cerevisiae durch gerichtete Evolution. Diplomarbeit, Universität Regensburg. Fulltext not available.

Plank, Maximilian (2007) Untersuchungen zu einer uncharakterisierten Proteingruppe mit (βα)₈-Faß Struktur: COG0325. Diplomarbeit, Universität Regensburg. Fulltext not available.

2006

Häger, Michaela C. (2006) Evolution und Regulation von Protein-Protein Interaktionen in zwei Glutamin-Amidotransferasen aus der Biosynthese von Histidin und Tryptophan. PhD, Universität Regensburg.

Giesecke, Astrid (2006) Protein-protein interactions mediated by Cys2His2 zinc-fingers. PhD, Universität Regensburg.

Leopoldseder, Sonja (2006) Neuartige Tryptophan-Synthasen aus Hyperthermophilen: Charakterisierung der Enzyme aus Sulfolobus solfataricus. PhD, Universität Regensburg.

Marino, Marco, Deuss, Miriam, Svergun, Dmitri I.

, Konarev, Petr V., Sterner, Reinhard

and Mayans, Olga

(2006) Structural and Mutational Analysis of Substrate Complexation by Anthranilate Phosphoribosyltransferase from Sulfolobus solfataricus. The Journal of Biological Chemistry 281 (30), pp. 21410-21421. Fulltext restricted.

Leopoldseder, Sonja, Hettwer, Stefan and Sterner, Reinhard

(2006) Evolution of multi-enzyme complexes: the case of tryptophan synthase. Biochemistry 45 (47), pp. 14111-9. Fulltext not available.

Schwab, Thomas (2006) Monomerisierung einer thermostabilen Anthranilat Phosphoribosyltransferase aus Sulfolobus solfataricus durch Proteindesign. Diplomarbeit, Universität Regensburg. Fulltext not available.

Bolz, Christian (2006) Mutationsanalyse zur Identifizierung der strukturellen Grundlage einer spezifischen Protein-Protein Interaktion. Diplomarbeit, Universität Regensburg. Fulltext not available.

Dumm, Bernhard (2006) Optimierung der Fremdaktivität eines (βα)₈-Barrel Enzyms aus der Histidinbiosynthese. Diplomarbeit, Universität Regensburg. Fulltext not available.

Seitz, Tobias (2006) Stabilisierung eines künstlich erzeugten (βα)₈-Barrel Proteins durch gelenkte Evolution. Diplomarbeit, Universität Regensburg. Fulltext not available.

Riede, Philipp (2006) Versuch der Etablierung einer neuen katalytischen Aktivität auf dem Proteingerüst der Indolglycerolphosphat Synthase aus Sulfolobus solfataricus. Diplomarbeit, Universität Regensburg. Fulltext not available.

2005

Marquardt, Susanne (2005) Biochemische Charakterisierung der ATP-Phosphoribosyltransferase (His(GSZ)₄-Komplex) aus Thermotoga maritima. Diplomarbeit, Universität Regensburg. Fulltext not available.

Sterner, Reinhard and Höcker, Birte

(2005) Catalytic versatility, stability, and evolution of the (betaalpha)8-barrel enzyme fold. Chemical reviews 105 (11), pp. 4038-55. Fulltext not available.

Dietrich, Susanne (2005) Enzymkinetische Untersuchungen zur evolutionären Verwandtschaft der Indolglycerolphosphat Synthase mit der α-Untereinheit der Tryptophan Synthase. Diplomarbeit, Universität Regensburg. Fulltext not available.

List, Felix (2005) Protein-Protein Wechselwirkungen innerhalb der Anthranilat Synthase aus Thermotoga maritima. Diplomarbeit, Universität Regensburg. Fulltext not available.

Vega, M. Cristina, Zou, Peijian, Fernandez, Francisco J., Murphy, Gavin E., Sterner, Reinhard, Popov, Alexander and Wilmanns, Matthias (2005) Regulation of the hetero-octameric ATP phosphoribosyl transferase complex from Thermotoga maritima by a tRNA synthetase-like subunit. Molecular microbiology 55 (3), pp. 675-86. Fulltext not available.

Schneider, Birgit, Knöchel, Thorsten, Darimont, Beatrice, Hennig, Michael, Dietrich, Susanne, Babinger, Karin, Kirschner, Kasper and Sterner, Reinhard

(2005) Role of the N-terminal extension of the (betaalpha)8-barrel enzyme indole-3-glycerol phosphate synthase for its fold, stability, and catalytic activity. Biochemistry 44 (50), pp. 16405-12. Fulltext not available.

2004

Lambeck, Iris (2004) Arbeiten zur Umwandlung der Tryptophansynthase α-Untereinheit aus Thermotoga maritima in eine Triosephosphatisomerase. Diplomarbeit, Universität Regensburg. Fulltext not available.

Sterner, Reinhard and Schmid, Franz X. (2004) Biochemistry. De novo design of an enzyme. Science (New York, N.Y.) 304 (5679), pp. 1916-7. Fulltext not available.

Thiemann, Volker, Dönges, Catharina, Prowe, Steffen G., Sterner, Reinhard and Antranikian, Garabed (2004) Characterisation of a thermoalkali-stable cyclodextrin glycosyltransferase from the anaerobic thermoalkaliphilic bacterium Anaerobranca gottschalkii. Archives of microbiology 182 (2-3), pp. 226-35. Fulltext not available.

Schneider, Birgit (2004) Die Rolle der N-terminalen Helix α0 in dem (βα)₈-Barrel Indolglycerolphosphat Synthase aus Thermotoga maritima und Sulfolobus solfataricus. Diplomarbeit, Universität Regensburg. Fulltext not available.

Leopoldseder, Sonja, Claren, Jörg, Jürgens, Catharina and Sterner, Reinhard (2004) Interconverting the catalytic activities of (betaalpha)(8)-barrel enzymes from different metabolic pathways: sequence requirements and molecular analysis. Journal of molecular biology 337 (4), pp. 871-9. Fulltext not available.

Höcker, Birte

, Claren, Jörg and Sterner, Reinhard

(2004) Mimicking enzyme evolution by generating new (betaalpha)8-barrels from (betaalpha)4-half-barrels. Proceedings of the National Academy of Sciences of the United States of America 101 (47), pp. 16448-53. Fulltext not available.

2003

Jaenicke, Rainer and Sterner, Reinhard (2003) Protein design at the crossroads of biotechnology, chemistry, theory, and evolution. Angewandte Chemie (International ed. in English) 42 (2), pp. 140-2. Fulltext not available.

2002

Höcker, Birte, Schmidt, Steffen and Sterner, Reinhard (2002) A common evolutionary origin of two elementary enzyme folds. FEBS letters 510 (3), pp. 133-5. Fulltext not available.

Hettwer, Stefan and Sterner, Reinhard (2002) A novel tryptophan synthase beta-subunit from the hyperthermophile Thermotoga maritima. Quaternary structure, steady-state kinetics, and putative physiological role. The Journal of biological chemistry 277 (10), pp. 8194-201. Fulltext not available.

Douangamath, Alice, Walker, Martina, Beismann-Driemeyer, Silke, Vega-Fernandez, M. Cristina, Sterner, Reinhard and Wilmanns, Matthias (2002) Structural evidence for ammonia tunneling across the (beta alpha)(8) barrel of the imidazole glycerol phosphate synthase bienzyme complex. Structure (London, England : 1993) 10 (2), pp. 185-93. Fulltext not available.

Henn-Sax, Martina, Thoma, Ralf, Schmidt, Steffen, Hennig, Michael, Kirschner, Kasper and Sterner, Reinhard (2002) Two (betaalpha)(8)-barrel enzymes of histidine and tryptophan biosynthesis have similar reaction mechanisms and common strategies for protecting their labile substrates. Biochemistry 41 (40), pp. 12032-42. Fulltext not available.

2001

Höcker, Birte, Beismann-Driemeyer, Silke, Hettwer, Stefan, Lustig, A. and Sterner, Reinhard (2001) Dissection of a (betaalpha)8-barrel enzyme into two folded halves. Nature structural biology 8 (1), pp. 32-6. Fulltext not available.

Henn-Sax, Martina, Höcker, Birte, Wilmanns, Matthias and Sterner, Reinhard (2001) Divergent evolution of (betaalpha)8-barrel enzymes. Biological chemistry 382 (9), pp. 1315-20. Fulltext not available.

Sterner, Reinhard (2001) Ferredoxin from Thermotoga maritima. Methods in enzymology 334, pp. 23-30. Fulltext not available.

Beismann-Driemeyer, Silke and Sterner, Reinhard (2001) Imidazole glycerol phosphate synthase from Thermotoga maritima. Quaternary structure, steady-state kinetics, and reaction mechanism of the bienzyme complex. The Journal of biological chemistry 276 (23), pp. 20387-96. Fulltext not available.

Sterner, Reinhard, Merz, A., Thoma, Ralf and Kirschner, Kasper (2001) Phosphoribosylanthranilate isomerase and indoleglycerol-phosphate synthase: tryptophan biosynthetic enzymes from Thermotoga maritima. Methods in enzymology 331, pp. 270-80. Fulltext not available.

Höcker, Birte, Jürgens, Catharina, Wilmanns, Matthias and Sterner, Reinhard (2001) Stability, catalytic versatility and evolution of the (beta alpha)(8)-barrel fold. Current opinion in biotechnology 12 (4), pp. 376-81. Fulltext not available.

Sterner, Reinhard and Liebl, W. (2001) Thermophilic adaptation of proteins. Critical reviews in biochemistry and molecular biology 36 (1), pp. 39-106. Fulltext not available.

2000

Jürgens, Catharina, Strom, A., Wegener, D., Hettwer, Stefan, Wilmanns, Matthias and Sterner, Reinhard (2000) Directed evolution of a (beta alpha)8-barrel enzyme to catalyze related reactions in two different metabolic pathways. Proceedings of the National Academy of Sciences of the United States of America 97 (18), pp. 9925-30. Fulltext not available.

Lang, Detlef, Thoma, Ralf, Henn-Sax, Martina, Sterner, Reinhard and Wilmanns, Matthias (2000) Structural evidence for evolution of the beta/alpha barrel scaffold by gene duplication and fusion. Science (New York, N.Y.) 289 (5484), pp. 1546-50. Fulltext not available.

Thoma, Ralf, Hennig, Michael, Sterner, Reinhard and Kirschner, Kasper (2000) Structure and function of mutationally generated monomers of dimeric phosphoribosylanthranilate isomerase from Thermotoga maritima. Structure (London, England : 1993) 8 (3), pp. 265-76. Fulltext not available.

1999

Thoma, Ralf, Obmolova, G., Lang, D. A., Schwander, M., Jenö, P., Sterner, Reinhard and Wilmanns, Matthias (1999) Efficient expression, purification and crystallisation of two hyperthermostable enzymes of histidine biosynthesis. FEBS letters 454 (1-2), pp. 1-6. Fulltext not available.

1998

Thoma, Ralf, Schwander, M., Liebl, W., Kirschner, Kasper and Sterner, Reinhard (1998) A histidine gene cluster of the hyperthermophile Thermotoga maritima: sequence analysis and evolutionary significance. Extremophiles : life under extreme conditions 2 (4), pp. 379-89. Fulltext not available.

1997

Hennig, Michael, Sterner, Reinhard, Kirschner, Kasper and Jansonius, J. N. (1997) Crystal structure at 2.0 A resolution of phosphoribosyl anthranilate isomerase from the hyperthermophile Thermotoga maritima: possible determinants of protein stability. Biochemistry 36 (20), pp. 6009-16. Fulltext not available.

Pfeil, W., Gesierich, U., Kleemann, G. R. and Sterner, Reinhard (1997) Ferredoxin from the hyperthermophile Thermotoga maritima is stable beyond the boiling point of water. Journal of molecular biology 272 (4), pp. 591-6. Fulltext not available.

Macedo-Ribeiro, S., Darimont, Beatrice and Sterner, Reinhard (1997) Structural features correlated with the extreme thermostability of 1[4Fe-4S] ferredoxin from the hyperthermophilic bacterium Thermotoga maritima. Biological chemistry 378 (3-4), pp. 331-6. Fulltext not available.

1996

Sticht, H., Wildegger, G., Bentrop, D., Darimont, Beatrice, Sterner, Reinhard and Rösch, P. (1996) An NMR-derived model for the solution structure of oxidized Thermotoga maritima 1[Fe4-S4] ferredoxin. European journal of biochemistry / FEBS 237 (3), pp. 726-35. Fulltext not available.

Sterner, Reinhard, Kleemann, G. R., Szadkowski, H., Lustig, A., Hennig, Michael and Kirschner, Kasper (1996) Phosphoribosyl anthranilate isomerase from Thermotoga maritima is an extremely stable and active homodimer. Protein science : a publication of the Protein Society 5 (10), pp. 2000-8. Fulltext not available.

Macedo-Ribeiro, S., Darimont, Beatrice, Sterner, Reinhard and Huber, R. (1996) Small structural changes account for the high thermostability of 1[4Fe-4S] ferredoxin from the hyperthermophilic bacterium Thermotoga maritima. Structure (London, England : 1993) 4 (11), pp. 1291-301. Fulltext not available.

Decker, H., Hartmann, H., Sterner, Reinhard, Schwarz, E. and Pilz, I. (1996) Small-angle X-ray scattering reveals differences between the quaternary structures of oxygenated and deoxygenated tarantula hemocyanin. FEBS letters 393 (2-3), pp. 226-30. Fulltext not available.

1995

Sterner, Reinhard, Dahm, A., Darimont, Beatrice, Ivens, Andreas, Liebl, W. and Kirschner, Kasper (1995) (Beta alpha)8-barrel proteins of tryptophan biosynthesis in the hyperthermophile Thermotoga maritima. The EMBO journal 14 (18), pp. 4395-402. Fulltext not available.

Wildegger, G., Bentrop, D., Ejchart, A., Alber, M., Hage, A., Sterner, Reinhard and Rösch, P. (1995) 1H nuclear-magnetic-resonance investigation of oxidized Fe4S4 ferredoxin from Thermotoga maritima. Hyperfine-shifted resonances, sequence-specific assignments and secondary structure. European journal of biochemistry / FEBS 229 (3), pp. 658-68. Fulltext not available.

Hennig, Michael, Darimont, Beatrice, Sterner, Reinhard, Kirschner, Kasper and Jansonius, J. N. (1995) 2.0 A structure of indole-3-glycerol phosphate synthase from the hyperthermophile Sulfolobus solfataricus: possible determinants of protein stability. Structure (London, England : 1993) 3 (12), pp. 1295-306. Fulltext not available.

Sterner, Reinhard, Vogl, T., Hinz, H. J., Penz, F., Hoff, R., Föll, R. and Decker, H. (1995) Extreme thermostability of tarantula hemocyanin. FEBS letters 364 (1), pp. 9-12. Fulltext not available.

1994

Sterner, Reinhard and Decker, H. (1994) Inversion of the Bohr effect upon oxygen binding to 24-meric tarantula hemocyanin. Proceedings of the National Academy of Sciences of the United States of America 91 (11), pp. 4835-9. Fulltext not available.

Darimont, Beatrice and Sterner, Reinhard (1994) Sequence, assembly and evolution of a primordial ferredoxin from Thermotoga maritima. The EMBO journal 13 (8), pp. 1772-81. Fulltext not available.

Sterner, Reinhard, Bardehle, K., Paul, R. and Decker, H. (1994) Tris: an allosteric effector of tarantula haemocyanin. FEBS letters 339 (1-2), pp. 37-9. Fulltext not available.

1990

Decker, H. and Sterner, Reinhard (1990) Nested allostery of arthropodan hemocyanin (Eurypelma californicum and Homarus americanus). The role of protons. Journal of molecular biology 211 (1), pp. 281-93. Fulltext not available.

Decker, H. and Sterner, Reinhard (1990) [Hierarchies in the structure and function of oxygen-binding proteins]. Die Naturwissenschaften 77 (12), pp. 561-8. Fulltext not available.

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