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CD83 expression is essential for Treg cell differentiation and stability

Doebbeler, Marina ; Koenig, Christina ; Krzyzak, Lena ; Seitz, Christine ; Wild, Andreas ; Ulas, Thomas ; Baßler, Kevin ; Kopelyanskiy, Dmitry ; Butterhof, Alina ; Kuhnt, Christine ; Kreiser, Simon ; Stich, Lena ; Zinser, Elisabeth ; Knippertz, Ilka ; Wirtz, Stefan ; Riegel, Christin ; Hoffmann, Petra ; Edinger, Matthias ; Nitschke, Lars ; Winkler, Thomas ; Schultze, Joachim L. ; Steinkasserer, Alexander ; Lechmann, Matthias


Foxp3-positive regulatory T cells (Tregs) are crucial for the maintenance of immune homeostasis and keep immune responses in check. Upon activation, Tregs are transferred into an effector state expressing transcripts essential for their suppressive activity, migration, and survival. However, it is not completely understood how different intrinsic and environmental factors control differentiation. ...


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