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Transition-State Ensembles Navigate the Pathways of Enzyme Catalysis

Mickert, Matthias J. ; Gorris, Hans H.



Abstract

Transition-state theory (TST) provides an important framework for analyzing and explaining the reaction rates of enzymes. TST, however, needs to account for protein dynamic effects and heterogeneities in enzyme catalysis. We have analyzed the reaction rates of beta-galactosidase and beta-glucuronidase at the single molecule level by using large arrays of femtoliter-sized chambers. Heterogeneities ...

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