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Alpha-syntrophin deficient mice are protected from adipocyte hypertrophy and ectopic triglyceride deposition in obesity

Eisinger, Kristina ; Rein-Fischboeck, Lisa ; Neumeier, Markus ; Schmidhofer, Sandra ; Pohl, Rebekka ; Haberl, Elisabeth M. ; Liebisch, Gerhard ; Kopp, Andrea ; Schmid, Andreas ; Krautbauer, Sabrina ; Buechler, Christa


Alpha-syntrophin (SNTA) is a molecular adapter protein which is expressed in adipocytes. Knock-down of SNTA in 3T3-L1 preadipocytes increases cell proliferation, and differentiated adipocytes display small lipid droplets. These effects are both characteristics of healthy adipose tissue growth which is associated with metabolic improvements in obesity. To evaluate a role of SNTA in adipose tissue ...


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