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A refined and translationally relevant model of chronic DSS colitis in BALB/c mice

Hoffmann, Maximilian ; Schwertassek, Ulla ; Seydel, Aleksandra ; Weber, Klaus ; Falk, Werner ; Hauschildt, Sunna ; Lehmann, Jörg



Abstract

Inflammatory bowel diseases (IBD) are chronic relapsing disorders of the gastrointestinal tract. Several mouse models for IBD are available, but the acute dextran sulfate sodium (DSS)-induced colitis model is mostly used for preclinical studies. However, this model lacks chronicity and often leads to significant loss of mice. The aim of this study was to establish a refined and translationally ...

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