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Chemerin in a Mouse Model of Non-alcoholic Steatohepatitis and Hepatocarcinogenesis




Abstract

Background/Aim: Non-alcoholic steatohepatitis (NASH) is a risk factor for hepatocellular carcinoma (HCC). The adipokine chemerin protects from HCC and is reduced in human HCC. In this study, chemerin expression was analyzed in a murine model of NASH-HCC. Materials and Methods: Serum and hepatic chemerin, and ex vivo chemerin receptor activation were monitored in NASH and NASH-HCC in mice fed a ...

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