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Cross-Inhibition of Norrin and TGF-β Signaling Modulates Development of Retinal and Choroidal Vasculature

Seitz, Roswitha ; Weber, Gregor ; Albrecht, Sebastian ; Fuchshofer, Rudolf ; Tamm, Ernst R. ; Ohlmann, Andreas



Abstract

PURPOSE. Norrin is essential for the formation of the retinal vasculature during development and promotes its repair after damage via activation of Wnt/beta-catenin signaling. Since retinal TGF-beta signaling has essentially opposite effects on the retinal vasculature we investigated if and how Norrin inhibits TGF-beta signaling, and vice versa. METHODS. Eyes from transgenic mice with an ...

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