| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | International Journal of Urology | ||||
| Publisher: | Wiley | ||||
| Place of Publication: | HOBOKEN | ||||
| Volume: | 25 | ||||
| Number of Issue or Book Chapter: | 5 | ||||
| Page Range: | pp. 442-449 | ||||
| Date: | 2018 | ||||
| Institutions: | Medicine > Lehrstuhl für Urologie | ||||
| Identification Number: |
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| Keywords: | SQUAMOUS-CELL CARCINOMA; PROGNOSTIC-SIGNIFICANCE; RISK STRATIFICATION; TUMOR; CLASSIFICATION; MULTICENTER; PROGRESSION; PROPOSAL; DEPTH; SIZE; instillation treatment; prognosis; stageT1 high-grade; tumor growth pattern; urothelial bladder cancer | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 47240 |
Web of ScienceAbstract
ObjectivesTo investigate established prognostic factors and relatively new histopathological tumor characteristics including metric substage and lamina propria invasion patterns in a large series of T1 high-grade non-muscle-invasive bladder cancer. MethodsBetween 1989 and 2012, 322 patients with initial stageT1 high-grade bladder cancer underwent transurethral resection, followed by ...
Abstract
ObjectivesTo investigate established prognostic factors and relatively new histopathological tumor characteristics including metric substage and lamina propria invasion patterns in a large series of T1 high-grade non-muscle-invasive bladder cancer. MethodsBetween 1989 and 2012, 322 patients with initial stageT1 high-grade bladder cancer underwent transurethral resection, followed by re-transurethral resection and a conservative approach with follow-up regime alone or instillation treatment. Transurethral resection specimens were reassessed by two experienced urological pathologists for tumor grade according to the World Health Organization 1973 classification, metric T1 substage, lamina propria invasion pattern and associated carcinoma insitu. The median follow-up period was 42months (interquartile range 25-72months). In addition to Kaplan-Meier analyses, uni- and multivariable Cox regression analyses were used to compare progression-free survival, cancer-specific survival and overall survival for the studied parameters comparing two subcohorts. ResultsWhile in patients after instillation treatment no examined feature was shown as an independent predictor for prognosis, there were predictive histopathological features in multivariable Cox regression analyses in instillation treatment-naive patients: associated carcinoma insitu (hazard ratio 2.278, 95% confidence interval 1.119-4.634, P=0.023) and World Health Organization 1973 grade3 (hazard ratio 2.950, 95% confidence interval 1.021-8.536, P=0.046) for worse progression-free survival, infiltrative lamina propria tumor pattern for worse cancer-specific survival (hazard ratio 2.369, 95% confidence interval 1.034-5.429, P=0.042) and overall survival (hazard ratio 1.049, 95% confidence interval 1.024-1.075, P=0.001). ConclusionsThe results of the present T1 high-grade bladder cancer series suggest that lamina propria invasion pattern is a promising parameter to predict the prognosis of T1 high-grade bladder cancer in an instillation treatment-naive subcohort. Prospective multicenter evaluations are warranted. The need for instillation treatment in T1 high-grade bladder cancer is clearly demanded.
Metadata last modified: 18 Aug 2021 13:14
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