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The Long Non-coding RNA lnc-31 Interacts with Rock1 mRNA and Mediates Its YB-1-Dependent Translation

Dimartino, Dacia ; Colantoni, Alessio ; Ballarino, Monica ; Martone, Julie ; Mariani, Davide ; Danner, Johannes ; Bruckmann, Astrid ; Meister, Gunter ; Morlando, Mariangela ; Bozzoni, Irene



Abstract

Cytoplasmic long non-coding RNAs have been shown to act at many different levels to control post-transcriptional gene expression, although their role in translational control is poorly understood. Here, we show that lnc-31, a non-coding RNA required for myoblast proliferation, promotes ROCK1 protein synthesis by stabilizing its translational activator, YB-1. We find that lnc-31 binds to the Rock1 ...

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