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Expanding the Genetic Code of Lactococcus lactis and Escherichia coli to Incorporate Non-canonical Amino Acids for Production of Modified Lantibiotics

Bartholomae, Maike ; Baumann, Tobias ; Nickling, Jessica H. ; Peterhoff, David ; Wagner, Ralf ; Budisa, Nediljko ; Kuipers, Oscar P.


The incorporation of non-canonical amino acids (ncAAs) into ribosomally synthesized and post-translationally modified peptides, e.g., nisin from the Gram-positive bacterium Lactococcus lactis, bears great potential to expand the chemical space of various antimicrobials. The ncAA N-epsilon-Boc-L-lysine (BocK) was chosen for incorporation into nisin using the archaeal pyrrolysyl-tRNA ...


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