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Blinatumomab for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukemia

Bargou, Ralf C. ; Nagorsen, Dirk ; Zugmaier, Gerhard ; Benjamin, Jonathan E. ; Haddad, Vincent ; Wessels, Hendrik ; Stieglmaier, Julia ; Havelange, Violaine ; Horst, Heinz-August ; Brüggemann, Monika ; Topp, Max S. ; Diedrich, Helmut ; Faul, Christoph ; Graux, Carlos ; Reichle, Albrecht ; Bonifacio, Massimiliano ; Dombret, Hervé ; Gökbuget, Nicola



Abstract

Approximately 30% to 50% of adults with acute lymphoblastic leukemia (ALL) in hematologic complete remission aftermultiagent therapy exhibit minimal residual disease (MRD) by reverse transcriptase-polymerase chain reaction or flow cytometry. MRD is the strongest predictor of relapse in ALL. In this open-label, single-arm study, adults with B-cell precursor ALL in hematologic complete remission ...

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