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Oxytocin Signaling in the Lateral Septum Prevents Social Fear during Lactation

Menon, Rohit ; Grund, Thomas ; Zoicas, Iulia ; Althammer, Ferdinand ; Fiedler, Dominik ; Biermeier, Verena ; Bosch, Oliver J. ; Hiraoka, Yuichi ; Nishimori, Katsuhiko ; Eliava, Marina ; Grinevich, Valery ; Neumann, Inga D.


Oxytocin (OXT)-mediated behavioral responses to social and stressful cues have extensively been studied in male rodents. Here, we investigated the capacity of brain OXT receptor (OXTR) signaling in the lateral septum (LS) to prevent social fear expression in female mice using the social-fear-conditioning paradigm. Utilizing the activated OXT system during lactation, we show that lactating mice ...


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