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Ex vivo analysis of serum chemerin activity in murine models of obesity

Haberl, Elisabeth M. ; Pohl, Rebekka ; Rein-Fischboeck, Lisa ; Feder, Susanne ; Eisinger, Kristina ; Krautbauer, Sabrina ; Sinal, Christopher J. ; Buechler, Christa



Abstract

Objectives: Chemerin is an adipokine with established roles in inflammation, adipogenesis and the regulation of glucose and lipid homeostasis. Extracellular proteolytic processing of chemerin generates a spectrum of isoforms that differ significantly with respect to the ability to activate the cognate receptors chemokine-like receptor 1 (CMKLR1) and G-protein-coupled receptor 1 (GPR1). Increased ...

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