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Hypertonicity primes malignant melanoma cells for apoptosis

Calance, Diana Nicoleta ; Steixner, Charlotte ; Gross, Stefanie ; Schuler-Thurner, Beatrice ; Knoll, Gertrud ; Ehrenschwender, Martin


The tumor environment critically influences responsiveness of cancer cells to chemotherapies, most of which activate the mitochondria-regulated (intrinsic) apoptotic cascade to kill malignant cells. Especially skin tumors encounter an environment with remarkable biophysical properties. Cutaneous accumulation of Na+ locally establishes osmotic pressure gradients in vivo (hypertonicity or ...


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