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Effects of supplemented isoenergetic diets varying in cereal fiber and protein content on the bile acid metabolic signature and relation to insulin resistance

Weickert, Martin O. ; Hattersley, John G. ; Kyrou, Ioannis ; Arafat, Ayman M. ; Rudovich, Natalia ; Roden, Michael ; Nowotny, Peter ; von Loeffelholz, Christian ; Matysik, Silke ; Schmitz, Gerd ; Pfeiffer, Andreas F. H.


Bile acids (BA) are potent metabolic regulators influenced by diet. We studied effects of isoenergetic increases in the dietary protein and cereal-fiber contents on circulating BA and insulin resistance (IR) in overweight and obese adults. Randomized controlled nutritional intervention (18 weeks) in 72 non-diabetic participants (overweight/obese: 29/43) with at least one further metabolic risk ...


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