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Phenytoin inhibits necroptosis

von Mässenhausen, Anne ; Tonnus, Wulf ; Himmerkus, Nina ; Parmentier, Simon ; Saleh, Danish ; Rodriguez, Diego ; Ousingsawat, Jiraporn ; Ang, Rosalind L. ; Weinberg, Joel M. ; Sanz, Ana B. ; Ortiz, Alberto ; Zierleyn, Adrian ; Becker, Jan Ulrich ; Baratte, Blandine ; Desban, Nathalie ; Bach, Stéphane ; Schiessl, Ina Maria ; Nogusa, Shoko ; Balachandran, Siddharth ; Anders, Hans Joachim ; Ting, Adrian T. ; Bleich, Markus ; Degterev, Alexei ; Kunzelmann, Karl ; Bornstein, Stefan R. ; Green, Douglas R. ; Hugo, Christian ; Linkermann, Andreas



Abstract

Receptor-interacting protein kinases 1 and 3 (RIPK1/3) have best been described for their role in mediating a regulated form of necrosis, referred to as necroptosis. During this process, RIPK3 phosphorylates mixed lineage kinase domain like (MLKL) to cause plasma membrane rupture. RIPK3-deficient mice have recently been demonstrated to be protected in a series of disease models, but direct ...

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